ate-络合物是由经典金属试剂衍生出的一类独具特色的金属试剂。文献中它们的种类、制备及配比、用途与反应等均较单一，仍有很大探索的空间。本项目旨在种类、制备与配料比、反应等多方面对ate-络合物进行拓展和革新。通过调整Lewis酸的中心原子与配体种类，采用亚化学计量或催化量的Lewis酸，设计合成出新型ate-络合物，建立只需亚化学计量或催化量 Zr、Al、In、Zn、Sn、B等元素参与的Negishi、Stille、Suzuki等偶联反应或其他高选择性反应。设计和研究双烃基或烃基、胺基混合型ate-络合物，开发出具有双功能的新型ate-络合物及反应。利用这些反应建立新的杂环合成法和高选择性不对称反应；最终进行药物、天然产物等新法合成。课题将较大程度上拓展ate-络合物种类、制备与相关反应，加深对ate-络合物结构与性能的理解，对丰富有机金属试剂及相关反应，深入了解协同效应机制等有重要的意义

Ate-complex is a class of unique metal reagents derived from the classic metal reagents through their combination with Lewis acid. The manners of their preparation, the ratios of metal reagent to Lewis acid, their functions and reactions were rather limited in literature reports. This project aims to enrich the chemistry of ate-complexes regarding their species, preparation, the ratios of metal reagent to Lewis, their functions and reactions. A variety of new ate-complexes will be designed and prepared by varying the central atoms and ligands of Lewis acids with the use of sub-stoichiometric or catalytic amount of Lewis acid, and thus the reactions such as Negishi, Stille, Suzuki coupling reactions using sub-stoichiometric or catalytic amount of Zr, Al, In, Zn, Sn, B, etc. compounds as well as other highly selective reactions will be established. Besides, the new types of mixed ate-complexes containing two different alkyl groups or one alkyl group with one dialkylamino group will be designed and prepared, and their multi-functions and reactions will be also explored. Furthermore, taking advantage of the functions and reactions of these new ate-complexes, the novel syntheses of heterocycles and highly stereoselective reactions will be developed as well. Finally, these achievements will be applied to the new total syntheses of pharmaceutically active compounds or natural products..This project will diversify the types of ate-complexes and greatly expand their preparations and the related reaction scopes. It will also help in further understanding the structures and reactivity of ate-complexes. Obviously, it will be of important significance to the development of the organometallic reagents and their reactions as well as the mechanism of synergic effect.