早期盆腹腔转移是卵巢癌临床治疗难点之一。课题组发现大黄素能抑制卵巢癌细胞的侵袭转移，调控其上皮-间质转化（EMT）过程，但具体机制不清。预实验发现骨形态发生蛋白-7（BMP-7）在转移肿瘤组织的表达较原位卵巢癌组织显著升高，提示BMP-7在卵巢肿瘤的侵袭转移中发挥重要作用，而大黄素可以降低BMP-7的表达。课题组推测：大黄素可以通过降低BMP-7的表达来抑制卵巢癌细胞侵袭。拟进一步研究：1. BMP-7/TGF-β1/Smads在正常卵巢、肿瘤组织中的表达及在转移中的作用及机制；2.体内外实验研究大黄素对卵巢癌细胞EMT的抑制作用，正、反向施加BMP-7和（或）TGF-β1干预，深入探讨大黄素调控BMP-7/TGF-β1/Smads通路对卵巢癌细胞EMT过程的影响。该研究结果将为中药防治卵巢癌转移提供可资借鉴的研究思路与方法，对促进大黄素临床推广应用具有重要的理论意义。

The early metastasis is one of the difficulties in clinical treatment of ovarian cancer. We identified that emodin could inhibits the metastasis of ovarian cancer cells and regulates the EMT process. The mechanisms is not clear. The results of our preliminary experiments shown that the expression of BMP-7 in metastatic tumor organ is significantly higher than in ovarian cancer tissues in situ.It reminds that BMP-7 may play an important role in the metastasis of ovarian cancer cells. In the meantime, we found that emodin could decrease the expression of BMP-7 in ovarian cancer cells. This might be related to its ability to inhibit ovarian cancer invasion. On the basis of previous foundings, we want to do further research with: 1. The expression of BMP–7、TGF-beta 1 、Smads in ovarian cancer and normal ovarian epithelial and their roles in the invasion process; 2. Do in vivo and in vitro tests to clear the effect of emodin in inhibiting the invasion of ovarian cancer cells ,We are trying to explain the mechanism of emodin to regulate the EMT factors by intervening BMP-7 and (or) TGF-beta 1. The research results will provide reference for TCM prevention and treatment of ovarian cancer metastasis and promote the clinical application of emodin.