以氨基酸的分级结晶拆分为模型，针对现有方法存在的结晶产率低、适用化合物少的问题，将具有手性识别功能的赖氨酸残基合理地引入到乙烯基和乙炔基单体的结构中，通过RAFT聚合和立构规整聚合，合成化学结构、拓扑结构、立体结构不同的聚合物；利用聚合诱导自组装，获得球形胶束、棒状胶束、囊泡等不同形貌的聚集体；将这些聚合物及其超分子聚集体用作典型氨基酸的晶核形成/生长抑制剂，深入了解不同层次结构对手性分离性能的影响。通过精确的结构设计和可控聚合反应，制备以带有赖氨酸残基的聚合物链段为壳、具有催化氨基酸消旋功能的聚合物链段为中间层、聚苯乙烯链段为核的核壳型纳米结构结晶抑制剂，实现结晶产率超过50%、ee值大于90%的氨基酸手性拆分。建立新的非均相分级结晶拆分方法，拓宽可拆分外消旋体的范围。为获得拆分效果好、结晶产率高、适用范围广、易于循环使用的手性高分子对映体选择性结晶抑制剂提供新的途径和理论依据。

Taking the fractional crystallization of amino acids as model, vinyl and ethynyl monomers with lysine residues are designed and synthesized to increase the crystallization yield of conglomerate forming enantiomers and enable the chiral resolution of racemic compound and pseudoracemate forming enantiomers. Polymeric enantioselective crystallization inhibitors with different chemical structures, stereostructures, and topological structures are prepared via RAFT polymerization and stereoregular polymerization. Aggregates of amphiphilic block copolymers with various morphologies such as spherical micelle, rod-like micelle, and vesicles are obtained via polymerization induced self-assembly in selective solvent. These optically active polymers and their aggregates are employed as the nucleation and growth inhibitors to transform the racemate of typical amino acids to one enantiomers. The effects of chain structure, topological structure, and hierarchical supramolecular structure on the chiral resolution performance are systematically investigated. Core-shell nanoparticle nucleation/growth inhibitors with polystyrene as the core, lysine residue bearing polymer as the shell, and the polymer capable of catalyzing racemization of amino acids as the intermediate layer are prepared to completely transform the racemate to one enantiomer. This study is also dedicated to the development of an efficient and facile optical resolution strategy based on novel polymeric inhibitors and the crystallization from emulsion. The success of this project will lay the foundations for the exploration of new polymeric inhibitors and chiral resolution method with excellent chiral resoluton formance, wide racemate families, and ready recyclability. It will also promote the development of chiral recognition and chiral separation functional polymer materials.