“肠造口”手术是目前“肛门失禁”治疗方案中的最后选择，它虽能挽救生命，但也是违反生理的残疾或畸形，患者将面临一系列生理、心理和社会等方面问题，使患者生存质量受到严重影响。为此，本项目拟开展“基于盆神经上行通路便意功能重建的原位植入仿生肛门括约肌系统研究”，具体内容：（1）通过 “人工肛门括约肌子系统”动作原理及与“直肠或肛管”作用时的柔顺性，系统“植入部分”材料选择、加工工艺及表面生物活化处理等方面研究，实现了患者“抑便和排便”功能重建，并保障“系统”长期在体时的生物相容性和安全性。（2）通过对“直肠或肛管”中粪便形态及量的检测、基于检测结果“盆神经”刺激电信号的构建、盆神经动作电位时相特征与排便关系的研究，实现患者“便意”功能重建。（3）基于生物电磁安全性要求，研究“无线供能子系统”，解决“系统”长期植入时能源供给问题，因此，开展本项目研究对于提高我国FI疾病诊治水平具有十分重要的意义。

Enterostomy is the final method of today’s treatment to Fecal incontinence. Such a treatment can rescue one’s life, but it will cause one’s physical disability and deformity. Patient after enterostomy will suffer series of physiological, psychological and social problems. Thus, the patient’ quality of life will be strongly influenced. Therefore, this project prepares to propose a research of the bionic orthotopic implantable artificial anal sphincter sysytem and regeneration of rectal perception based on pelvic nerve ascending pathway. The detailed contents of this project include: (1) Rebuilding the patient’s defecation system, and guaranteeing the long-term implantation and biocompatibility of the artificial anal sphincter through theory of motion of the artificial anal sphincte, flexibility of rectal tube when it contacts with the artificial anal sphincte, material selection of implant part of the artificial anal sphincte, process of manufacturing the artificial anal sphincte and study of surface biological activation of the artificial anal sphincte. (2) Rebuilding the perception of patient’s rectal tube via detecting the formation and quantity of feces, construction of signal of stimulation of pelvic nerve, and study of relationship of features of motion of pelvic nerve of potential in its time phase and corresponded fecal situation. (3) Researching the powerful wireless power transmit system that manage to supply sufficient power for long-term implantation of the artificial anal sphincte under the rule of biocompatibility of electromagnetism. All contents make the project significant in improving the level of treatment of FI in China.