胃肠道疾病的发病率和死亡率逐年升高，已成为国际社会研究和防控的重点。现有医学水平虽可以干预组织癌变的进程甚至治愈早期癌，但目前存在的困难是：缺乏对胃肠道恶性肿瘤早期和无创的检测方法和手段；同时，胃肠道功能性疾病已成为危害人民健康和生命质量的顽症，对该类疾病发病机制的诊断依赖于胃肠道生理参数的无创检测，但目前的检测技术和手段存在缺陷。本项目基于早发现、早诊断和早治疗的诊疗模式的发展需求，针对胃肠道恶性肿瘤、胃肠道功能性疾病的早期和无创诊查问题，在现有研究工作的基础上，以活体动物试验和活体动物胃肠道疾病模型为研究对象，通过对在胃肠道内可控运动、能对塌陷和褶皱的胃肠道实施径向扩张的微型仿生机器人技术，面向人体环境的无线能量传输技术，胃肠道腔内压力、温度、pH值和组织图像的无创检测及传输技术、检测数据处理技术等方面的研究，解决胃肠道疾病的早期和无创诊查问题，为进一步的人体临床应用奠定理论基础。

The incidence and mortality of gastrointestinal diseases are increasing year by year, it has become the focus of international research, prevention and control. The early-stage cancer can be cured and canceration can be intervened by the present medical level, but there are still some difficulties at present. Firstly, it is lack of early-stage and noninvasive detection methods and means for gastrointestinal malignant tumor. And secondly, the gastrointestinal functional disease has become a danger to people's health and living standard as the persistent ailment, the diagnosis of mechanisms of these diseases is dependent on the noninvasive detection of gastrointestinal physiological parameters, but the current detection technique and means exist defects. Basing on the existing research, this project regard the gastrointestinal tract of living animal as the research object. Through exploring the bionic micro-robot technique that the robot can be controlled to locomote in the gastrointestinal tract and expand radially in the collapsed and folded gastrointestinal tract, the noninvasive detection technique of pressure, temperature, pH value and tissue image in the gastrointestinal tract and the detected data transmission and processing technique, the project aim at solving the problems of the early-stage and noninvasive detection methods for the gastrointestinal disease, and to lay a theoretical foundation for further clinical application.