1,3-环戊烯二酮结构单元构建新方法和若干活性天然产物全合成研究

1,3-环戊烯二酮结构单元是一类存在于多个具有重要生物活性天然产物中的基本分子骨架，实现其简洁高效的构建对相应多个活性天然产物的合成研究具有重要意义。本课题拟对1,3-环戊烯二酮结构单元发展出一种新颖的环丁烯二酮达森/扩环构建方法，并以该方法为基础，实现nostotrebin 6的首次全合成和asterredione、bi-linderone的首次不对称全合成。

1,3-cyclopentenedione units exist in the core skeleton of a number of natural products having important biological activities. It is meaningful for synthetic studies on these bioactive natural products to disclose a concise and efficient construction method to this unit. This project is going to develop a new approach to the 1,3-cyclopentenedione units through a Darzens/ring expansion process of cyclobutenedione. Moreover, studies on the first total synthesis of nostotrebin 6 and the first asymmetric total synthesis of asterredione and bi-linderone will be carried out on the basis of the new approach to 1,3-cyclopentenedione units.