红景天苷(Salidroside, Sal)是高原珍贵药材红景天中最主要成分之一，具有广泛的药理作用。本课题组在apoE-/-自发动脉粥样硬化(atherosclerosis, AS)小鼠和db/db自发2型糖尿病(type 2 diabetes mellitus, T2DM)小鼠动物实验中分别发现，Sal兼具明显的抗AS和T2DM的药理作用，分析Sal很可能作用于AS和T2DM发病中的共同环节- - 脂质大分子跨内皮细胞转运的增强。根据进一步发现的预实验线索，本项目拟深入研究Sal通过干预小凹调节蛋白cavin-1与小凹蛋白caveolin-1结合和抗活性氧作用来调控脂质大分子(LDL, 脂肪酸-白蛋白复合物)跨ECs转运的分子机制，可望阐明红景天苷抗AS和T2DM的关键机制，为其转化应用奠定基础，也可深化对AS和T2DM发病机制的认识，有助于发现更多防治AS和T2DM的新思路和新靶点。

Salidroside (Sal) is the most important component of the plateau precious herbs Rhodiola and has a wide range of pharmacological effects. Our group found in apoE-/ - spontaneous atherosclerosis (AS) mice and db/ db spontaneous type 2 diabetes (T2DM) mice animal experiments, Sal has both anti-AS and anti-T2DM activity, indicating Sal is likely to act on a common link in AS and T2DM: reinforced transportation of lipid macromolecules across endothelial cell barriers. According to the clues obtained in further preliminary experiments, this project intends to in-depth research the molecular mechanisms of Sal activity on the inhibition of the transportation of lipid macromolecules (LDL, Fatty acid-Albumin complex) across ECs through interfering with the binding of caveolae regulatory protein, cavin-1 with caveolin-1 and its reactive oxygen species scavenging effects. These studies will help clarify the key mechanisms responsible for the anti-AS and anti-T2DM activity of Sal and lay the foundation for its translational application, as well as to deepen the understanding of the pathogenesis of AS and T2DM and to identify novel strategies or targets for the prevention or treatment of AS and T2DM.