口腔黏膜病是常见口腔疾病。病损部位局部给药是其重要治疗手段，具有给药方便、全身毒副作用小等优点。口腔黏膜黏附制剂是口腔黏膜疾病最有前途的局部给药方式之一。然而，现有制剂在口腔潮湿环境中存在黏附力不足、释药过快的缺点，是临床应用的瓶颈。贻贝是一种拥有强大湿粘接能力的海洋生物，被广泛应用于生物学领域。本课题组前期初步制备了一种仿贻贝湿粘接特性的聚乙烯醇新型载药贴膜，其微观结构提示该贴膜可能与口腔黏膜表面发生复杂的理化反应而增加湿粘接效果，而所载药物也可能达到较为理想的控释和缓释。基于此，本项目拟进一步完善该新型贴膜的构建方案，优化制备参数；通过体内外药物释放模型阐释该贴膜的药物缓释效果和机理；通过贴膜与黏液层之间的相互作用强度、扩散情况、化学键合机制三个方面的系统研究，揭示该贴膜与口腔黏膜表面的黏附能力和黏附机制。本项目的研究可为口腔黏膜疾病个性化局部给药系统的设计和开发提供新的思路和理论支持

Oral mucosa diseases are among the most common diseases affecting humans, and they can be effectively treated by topical therapeutic approaches, thanks to easy accessibility of the oral cavity. Mucoadhesives are one of the most promising topical therapeutic approaches for oral mucosal diseases. However, the lack of mucoadhesion in oral environment and burst drug release remains to be solved. Mussel is well known for its remarkable water resistance characteristic in addition to its biocompatibility, which makes it a potential ideal tissue adhesive in the biological field. We have previously established a mussel-inspired polyvinyl alcohol mucoadhesive drug delivery film, which shows a large increase in mucoadhesion by forming both covalent and non-covalent bonds with mucin. In addition, this mucoadhesive film also exhibited controlled drug release behavior. Based on our previous findings, this study aims to identify the best formulations for the mucoadhesive film through a comprehensive performance evaluation. Moreover, both in vivo and in vitro studies would be carried out to understand the drug release kinetics and mechanisms. Finally, the basics and underlying mechanisms of mucoadhesion would also be investigated by means of mucus-mucoadhesive polymer interaction studies, diffusion studies, and molecular scale testing of mucoadhesion. In summary, the results of the present study might provide new insights into the development of individualized local drug delivery systems for oral mucosa diseases.