过渡金属催化的不对称烯丙基取代反应可以同时构建手性中心和引入双键，在复杂化合物合成中具有重要应用价值。之前所报道的高区域和对映选择性的反应通常需要昂贵的过渡金属。本项研究的重点是找到合适的配体体系，用于自然界丰度较大的钴催化的烯丙基化反应，以代替同族的铑和铱，实现高反应活性和选择性。同时希望利用钴催化剂在抑制beta-氢消除和促进大位阻碳碳键形成的性质，实现更有挑战性的四级手性中心的选择性构建。本项工作拟研究稳定钴催化剂前体的制备，避免原位还原所需的还原剂的加入，促进钴催化的有机化学的发展。

Transition-metal catalyzed asymmetric allylic substitution reactions can construct chiral centers and introduce versatile double bond at the same time, which can be applied in the synthesis of complex molecules. High regio- and enantioselectivities could usually be obtained by the catalysis of precious transition metals, such as palladium, iridium, rhodium and ruthenium. Cheap base metal cobalt catalyzed selective allylation reaction, especially highly reactive and enantioselective version has not been developed so far. The main aim of this research is to find suitable ligand system which can be used in cobalt-catalyzed selective allylations. According to cobalt's unique property of avoiding beta-hydride elimination and promotion of hindered carbon-carbon bonds formation, more challenging reactivities over iridium and rhodium are expected to be developed, such as the construction of quaternary carbon centers. Stable cobalt precursors are expected to be synthesis in this project to avoid the state-of-art addition of reductants in situ, which may be important for the further development of cobalt catalyzed organic synthesis.