铝基局域表面等离子体共振(LSPR)传感器具有材料便宜、制备成本低、仪器结构简单、集成度高和可获得分子结构信息等优势，可作为移动医疗、食品安全和环境监测等领域终端装置的核心部件，引起了人们的关注和重视。但迄今为止，铝基LSPR传感器灵敏度低且表面修饰仍缺乏有效方法，制约着它的生化检测研究和广泛应用。本研究组初步研究发现，准三维纳米结构可提高铝基LSPR传感器的灵敏度，需要深入和系统研究。本项目通过纳米加工技术可控制备几种准三维铝基纳米有序结构，并在其表面修饰特异性敏感薄膜构建高选择性LSPR传感器。通过理论计算和实验表征系统研究纳米阵列结构、修饰材料和修饰膜厚度等与传感性能的关系，继而获得具有高灵敏度和合适检测线性范围的铝基LSPR生物传感器，实现硫化氢、氢离子和胃蛋白酶原等来自口腔和胃的生化分子离子的快速检测。这些工作将有助于LSPR科学仪器的研发和实现生化检测装置的便携化。

Aluminum (Al) based localized surface plasmon resonance (LSPR) sensor holds the advantages of low price and low fabrication cost, simple instrument setup, high density integration and synchronously qualitative detection, thus makes it a potential key component of terminal devices for mobile healthcare, environmental monitoring, food safety, etc., and has been attracting people's attention. Unfortunately, the low sensitivity and the lack of surface modification methods hinder its wide application. Our preliminary results showed that quasi-3D nanostructures could improve the sensitivity of Al based LSPR sensors, and this finding needs in-depth and systematic research. In this project, we firstly apply nanofabrication methods to prepare several types of quasi-3D well-defined nanostructures of Al, coat sensing layers on the surface of Al nanostructures to prepare LSPR biosensors with high selectivity. Then, through experimental characterization and theoretical simulation of the LSPR biosensors, we systematically study the effects of the nanostructure, sensing material, modification method and the thickness of sensing layer on the properties of LSPR sensors, in order to produce high-performance sensors with high selectivity and appropriate linear range of detection. Last, the sensors are applied for the rapid detection of the concentrations of H2S, H+ and pepsinogen which exist in mouth and stomach. The breakthrough in this research will greatly promote the development of LSPR-based scientific instruments and realize the portability of biochemical detection devices.