阻断CD8+T细胞功能衰竭，逆转上皮异常增生是受关注的新领域，但如何利用此类细胞表面不同的分子标志预判其逆转潜能是学科的前沿（SCIENCE, 2016）。我们发现，口腔白斑病（OLK）组织中存在CD8+T淋巴细胞功能衰竭表型，结合相关的研究，因此假设：CD8+T淋巴细胞功能衰竭可促进OLK异常增生的衍进，若恢复其功能，可逆转此进程。为印证该假设，拟研究：①OLK衍进中是否存在CD8+T淋巴细胞功能衰竭，其与OLK病理分级和预后的关系如何？②OLK中衰竭性CD8+T淋巴细胞是否存在优势亚群，其表面表达的分子标志是否具临床治疗指示意义？③OLK衍进中，导致CD8+T细胞功能衰竭的分子机制是什么？研究不仅有助于寻找针对OLK更有效的逆转靶点,也为阐明利用CD8+T细胞表面的分子标志预判其治疗潜能提供了范例。

Inhibiting the exhausting progression of CD8+ T cell and reversing the abnormal proliferation of epithelum is new field, which has been notably concerned. How utilize these special makers of these cells to predict its reversal potential is the frontier subjects of this field (SCIENCE, 2016). We found that the exhaustion of CD8+ T cell may exist in the oral leukoplakia (OLK). Researching on relevant papers, we proposed that CD8+ T cell exhaustion may prompt OLK tissue taking malignant manner, so restoring the normal function of these cells may be an alternative way to reverse the feasibility of OLK canceration. In order to verify the hypothesis, three studies are designed. ① Whether the exhausted CD8+ T cell existing in OLK, and whether these cells correlated with pathological grades and prognosis. ② Which subset of exhausted CD8+ T cell is the dominant one in OLK. Could We futher take full use of this molecular subtyping to guid clinical treatment? ③ Futher studies will be designed to elucidate the molecular mechanisms of exhaustion in CD8+ T cell, which may provide a new strategy to reverse the feasibility of OLK canceration. The objective of the study will not only help to find more effective against OLK therapeutic targets, and to elucidate the pathogenesis of abnormal epithelial hyperplasia diseases provides the basis for further.