挑食厌食是儿科常见疾病，且目前临床干预效果不显著，厌食行为的调控机制亟待深入研究。基于申请人过往摄食行为及学习记忆的神经机制研究的经验，以及中央杏仁核GABA(A)受体调控厌食行为的最新预实验结果，本项目利用中央杏仁核细胞类型特异性驱动Cre表达的工具小鼠，通过构建厌食模型小鼠以及病毒介导的分子遗传学、光/化学遗传学、定点药理学等在体干预手段，结合生物化学与分子细胞生物学、电生理学及行为学，系统研究中央杏仁核GABA(A)受体参与厌食相关环路调控的分子和细胞机制，为理解厌食行为的神经调控机制提供新的思路，为临床发展厌食干预新策略提供理理论依据。

Anorexia is a high prevalence disease for children. At present, clinical intervention is lack of effect, so the mechanism of Anorexia need further study. Based on the previous experience on neuronal mechanism of the feeding behavior and related learning and memory, as well as the new results about regulation of Central Amygdala (CeA) GABA (A) receptor on the anorectic behavior, the present project will study the molecular and cellular mechanism of central amygdala GABA (A) receptors regulating the anorectic behavior by in-situ injection of virus and drugs, behavioral assessment, electrophysiology in addition to biochemical and molecular techniques. The present project will shed more light on understanding the neuronal mechanism of anorectic behavior and provide theoretical basis for new strategy of anorexia intervention.