激光散斑衬比成像是近年兴起的血流成像新方法，具有快速、高分辨、操作简便等优势，在生物医学领域得到越来越多的应用。然而，目前其理论模型中对生物组织散射特性及血流运动形式采用了简单的近似处理，虽在血流速度相对变化率的半定量研究中取得了较好效果，但仍不足以进行血流速度的准确定量检测。提高其血流检测准确性的关键在于更精确地描述相干光在动态变化的复杂生物组织中传输时，后向散射光的电场自相关函数特性，进而完善激光散斑空间衬比、时间衬比等统计量与血流之间的定量关系。因此，本项目拟发展基于多GPU的动态生物组织电场蒙特卡洛模拟方法，深入研究相干光在含有血流的复杂动态生物组织中的传输规律，获取生物组织结构与光学特性，血管形态尺寸及其所处位置，血流运动形式，成像系统照明与探测方式等因素对散射光电场自相关函数特性影响的规律，完善激光散斑血流成像模型，发展激光散斑血流定量检测方法，提高激光散斑成像血流检测准确性。

Laser speckle contrast imaging of biological blood flow has attractive extensive attention in biomedical application due to its advantage of high spatio-temporal resolution, and easy to operate. However, the approximation on the scattering behavior and flow distribution adopted in its current physical model make it difficult to perform an accurate quantitative measurement of absolute blood flow velocity. To improve the accuracy of the quantitative blood flow measurement of laser speckle contrast imaging, we proposed to develop the GPU accelerated electrical field Monte-carlo simulation method to investigate the propagation of coherent light in complex dynamic biological tissue which contains blood vessels and blood flow.