手性药物研究在药物研发和工业生产中占有重要地位，建立性能优越的手性对映体拆分方法意义重大。毛细管开管柱电色谱（OT-CEC）是一种极具潜力的手性分离方法，但仍具有一定的局限性，难以满足日益繁重的手性分离任务，因此开发基于新材料的OT-CEC拆分方法十分重要。金属有机框架材料（MOFs）的独特优势，使其在OT-CEC分离体系中有良好的应用前景。目前MOFs在OT-CEC手性分离中的应用还较少，且缺乏系统性研究及相关机理探索。鉴于此，本项目拟在前期基础上，设计制备多种非手性、含手性配体和具有螺旋结构的MOFs修饰的开管柱；根据非手性修饰、手性协同和手性单拆三种CEC构建模式，建立基于MOFs开管柱的OT-CEC手性拆分体系；通过计算机分子模拟探索手性识别机理；最后用于实际样品的光学纯度鉴定。本项目的开展有助于推动MOFs在OT-CEC手性拆分领域的应用，为手性药物的研发和质控提供有力支撑。

Chiral drug research plays an important role in drug development and industrial production. It is significant to establish efficient methods for separating enantiomers. Open-tubular capillary electrochromatography (OT-CEC) is a promising method for chiral separation; however, the certain limitations of OT-CEC struggle to meet the increasingly onerous task of enantioseparation. Therefore, the exploration of novel materials to establish more efficient OT-CEC chiral separation systems is important. The unique advantages of metal organic framework materials (MOFs) implicate their good application prospects in OT-CEC enantioseparation. At present, the study of MOFs in OT-CEC is limited, and lack systematicness and exploration of relavant mechanism. In this project, we will design and synthesize MOFs (such as achiral, chiral ligands and helical structures) to prepare open tubular capillary column. Then MOFs modified OT-CEC enantioseparation system will be constructed based on three established methods for OT-CEC systems (achiral MOFs modified system, chiral MOFs synergetic system and chiral MOFs single system). Furthermore, the chiral recognition mechanism of MOFs stationary phase will be explored through molecular modeling technique. The novel OT-CEC system will be utilized to identify the optical purity of real sample. This project will contribute to broaden application of MOFs in capillary electrochromatography for enantioseparation and provide support for the development and quality control of chiral drugs.