MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography.
MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography.
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基于MIL-53的同型金属有机框架，作为开放式毛细管电典的固定阶段。
DOI：
10.1016/j.jpha.2021.12.004
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发表时间：
2022-06
影响因子：
8.8
通讯作者：
Chen, Qin
中科院分区：
文献类型：
--
作者：
Sun, Xiaodong;Niu, Bing;Zhang, Qi;Chen, Qin
关键词：
同手性金属有机骨架在手性催化、手性色谱等领域有着广泛的应用。然而，只有少数纯手性MOFs可以有效地用于毛细管电色谱（CEC），其性能远远不够。在本研究中，我们成功地合成了非手性纳米晶MIL-53。然后实施容易的合成后修饰策略以官能化产物，产生纯手性M0 F：I-His-NH-MIL-53。然后将该MOF用作开管CEC模式（OT-CEC）中的手性涂层，因此，它对几种外消旋药物表现出高的对映选择性。使用透射电子显微镜、扫描电子显微镜（具有能量色散X射线光谱）、傅里叶变换红外光谱、X射线衍射、热重分析、圆二色谱、Brunauer-Emmett-Teller表面积测量和X射线光电子能谱对纯手性MOF和所制造的毛细管涂层进行系统地表征。该研究为设计和建立基于MOF的手性OT-CEC体系提供了新的策略。制备了一种新型的OT-CEC手性固定相l-His-NH-MIL-53。采用多种方法来表征MOF和MOF涂层。MOF修饰毛细管对几种外消旋药物表现出很高的对映选择性。
Homochiral metal-organic frameworks (MOFs) have attracted considerable attention in many fields of research, such as chiral catalysis and chiral chromatography. However, only few homochiral MOFs can be effectively used in capillary electrochromatography (CEC) and their performances are far from adequate. In this study, we successfully synthesized achiral nanocrystalline MIL-53. A facile post-synthetic modification strategy was then implemented to functionalize the product, yielding a homochiral MOF: l-His-NH-MIL-53. This MOF was then employed as a chiral coating in open-tubular CEC mode (OT-CEC), and, as such, it exhibited high enantioselectivities for several racemic drugs. The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electron microscopy, scanning electron microscopy (with energy-dispersive X-ray spectrometry), Fourier-transform infrared spectroscopy, X-ray diffractometry, thermogravimetric analysis, circular dichroism spectroscopy, Brunauer-Emmett-Teller surface area measurements, and X-ray photoelectron spectroscopy. This study is expected to provide a new strategy for the design and establishment of MOF-based chiral OT-CEC systems. l-His-NH-MIL-53 was prepared as a novel chiral stationary phase for OT-CEC. Multiple methods were employed to characterize the MOF and MOF coating. MOF-modified capillary exhibited high enantioselectivity for several racemic drugs.
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