有害生物抗药性爆发是农业生产所面临的重大挑战，而治理有害生物抗药性的根本途径就是持续创制出具有全新作用机制的生态农药新品种。本项目围绕新作用靶标新作用机制的发现这一关键科学问题，将化学生物学前沿技术与功能基因组学、蛋白质组学、结构生物学、生物信息学技术以及分子模拟技术进行交叉集成，采取“从化学小分子探针到新靶标新机制发现”和“从靶标组结构到生态农药先导化合物设计”两条途径，开展以农药活性小分子为探针发现新农药作用靶标及新机制、调控蛋白-蛋白相互作用的小分子探针设计及其农药活性研究、针对新靶标蛋白或新结合位点的生态农药分子设计与合成等三个方面的研究，建立化学生物学导向的农药作用靶标发现及基于靶标组结构的生态农药分子设计的创新研究体系，创制出1~2个生态农药候选新品种。本项目的实施将进一步推动我国农药科学基础理论研究的创新发展，为将我国早日建成世界农药科技强国做出积极贡献。

Explosive development of pest resistance is one of the biggest challenges that agriculture production is facing. The fundamental way to combat pest resistance is to continually develop new ecological pesticide with new mode of action. Therefore, identification of novel action target or action mode is one of the most important scientific problems for the pesticide discovery. By integrating the cutting-edge techniques of chemical biology with functional genomics, proteomics, structural biology, bioinformatics and molecular simulations, this project will be carried out via two approaches, from small molecular chemical probe to identification of new action target and from the structure of targetome to molecular design of ecological pesticide lead compound. This project includes three parts: chemical probe-based identification of new action target and mechanism, molecular design and pesticidal activity of chemical probes for the regulation of protein-protein interaction, and molecular design and syntheses of ecological pesticide with new action target or new binding sites. The objective of this project is to establish an innovative research system of chemical biology-oriented identification of new action target and targetome-based design of ecological pesticide. The implementation of this project will further promote the development of pesticide innovation and basic research of pesticide science in China, and make a positive contribution to the establishment of China as a world pesticide science and technology center in the world.