已有研究表明家蚕核型多角体病毒感染后会诱导家蚕出现狂躁爬行的行为，该现象被认为增加了病毒的传播，是病毒操控宿主的生物学现象。然而，病毒感染改变宿主行为的分子机制尚不清楚。昆虫大脑中枢等神经系统是进行各项生命活动的指挥中心，在调节行为变化中发挥重要作用，因此，病毒感染引起宿主行为变化很可能是由于病毒作用于大脑所致，分析病毒感染对宿主神经系统的影响是阐明其分子机制的关键。本研究拟利用转录组学、蛋白质组学以及代谢组学等研究BmNPV感染后家蚕大脑等在基因转录、蛋白质表达以及代谢物的变化，重点分析与行为调控和运动相关的蛋白质、神经肽、蛋白类激素的变化规律，找出差异显著的作用靶标，阐明它们的生物学功能和作用通路，揭示参与调节宿主行为的分子机制。本研究结果将推进对杆状病毒-宿主互作、病毒感染-昆虫神经系统-行为调节作用分子机制的深入理解，同时也将为杆状病毒作为生物杀虫剂的开发利用提供新思路。

It was known that the silkworm larvae could be induced to displays enhanced locomotor activity (ELA) following infection with BmNPV. This phenomenon is thought that the virus controls and manipulates the host to increase the viral transmission. However, the mechanism of the virus changing the host’s behavior is unclear. As all of insect behaviours are controlled by the central nervous system (CNS), therefore understanding the effect of viral infection on host’s nervous system will be very important to discover the mechanism of this event. In this study, by using the transcriptomics, proteomics and metabonomics to analyze the changes of gene expression and proteins expression, as well as metabolites between the BmNPV-infected larvae and non-infection control groups, focusing on the important target proteins, nervous peptides and hormones that involved in behaviour regulation and movement, making clear their biological function, pathway and mechanism in regulating the behaviour after BmNPV infection. The results from this study will help to deeply understand the interaction between baculovirus-insect, viral infection-host nervous system-viral infection induced host behaviour, meanwhile it will favour the development of novel biopesticide by using baculovirus.