房颤、室速、室颤等复杂心律失常是当前心血管研究的重点，心内膜和对应心外膜区域的联合标测是复杂心律失常的特有研究需要，而现有的标测手段均无法做到。三维标测系统是目前最先进的心内膜标测系统，但迫于开胸实验中操作对心脏的牵拉和电介质的改变，无法用于心外膜标测。因此，我们拟在基于磁定位系统的三维标测与成像技术等前期工作的基础上，重点突破心内膜、心外膜联合标测技术和频谱分析等关键技术，研发心外膜多极同步标测导管等核心部件，获得心内膜、心外膜联合标测仪器成品，使之既能在心脏位置及形态相对固定时进行标测，也可在心脏形态和位置发生变化时（如开胸直视下研究时）进行心外膜标测，以满足复杂心律失常心外膜电生理机制研究的需要。

Complex arrhythmias including atrial fibrillation, ventricular tachycardia and ventricular fibrillation are the key point in current cardiovascular research. Mechanism research of complex arrhythmias needs for mapping of both endo- and epicardium, which is not met by current mapping methods. Of them, three-dimensional mapping is the most advanced method. However, its application is limited in epicardial mapping due to change of heart morphology and electrical field by operation manipulation. Thereby, we plan to develop combined endo- and epicardial.mapping device based on our previous work on 3-D magnetic localization mapping technology, including research on combined endo- and epicardial mapping and frequency spectral analysis and development of multiple lead simultaneous epicardial mapping catheter. This program will provide epicardial mapping device for and give an impetus to electrophysiological research of complex arrhythmias.