Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy.
Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy.
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DOI：
10.1021/nn506757x
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发表时间：
2015-01-27
期刊：
影响因子：
17.1
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Liu, Teng;Shi, Sixiang;Liang, Chao;Shen, Sida;Cheng, Liang;Wang, Chao;Song, Xuejiao;Goel, Shreya;Barnhart, Todd E.;Cai, Weibo;Liu, Zhuang
关键词：
用于体内癌症诊断和治疗的Theranostics通常需要设计良好的具有多种集成功能的纳米平台。在本研究中，我们发现功能化的氧化铁纳米颗粒(IONPs)可以通过硫化自组装在二维MoS2纳米片的表面，形成MoS2-IO纳米复合材料，然后用两种类型的聚乙二醇(PEG)对其进行修饰，以增强其在生理环境中的稳定性。有趣的是，~(64)Cu是一种常用的正电子发射放射性同位素，它可以牢固地吸附在MoS_2表面，而不需要螯合分子，从而实现了体内正电子发射断层扫描(PET)成像。另一方面，MoS_2-IO-PEG的强近红外(NIR)和超顺磁性也可分别用于光声断层扫描(PAT)和磁共振(MR)成像。在这种三模式成像的指导下，最终在体内进行光热治疗，在动物肿瘤模型上实现了有效的肿瘤消融。三模式成像发现了MoS2-IO-(D)PEG静脉注射后有效的肿瘤滞留。我们的研究强调了构建基于2D过渡金属二卤化物的多功能医用纳米复合材料用于多模式成像指导癌症治疗的前景。
Theranostics for in vivo cancer diagnosis and treatment generally requires well-designed nanoscale platforms with multiple integrated functionalities. In this study, we uncover that functionalized iron oxide nanoparticles (IONPs) could be self-assembled on the surface of two-dimensional MoS2 nanosheets via sulfur chemistry, forming MoS2-IO nanocomposites, which are then modified with two types of polyethylene glycol (PEG) to acquire enhanced stability in physiological environments. Interestingly, 64Cu, a commonly used positron-emitting radioisotope, could be firmly adsorbed on the surface of MoS2 without the need of chelating molecules, to enable in vivo positron emission tomography (PET) imaging. On the other hand, the strong near-infrared (NIR) and superparamagnetism of MoS2-IO-PEG could also be utilized for photoacoustic tomography (PAT) and magnetic resonance (MR) imaging, respectively. Under the guidance by such triple-modal imaging, which uncovers efficient tumor retention of MoS2-IO-(d)PEG upon intravenous injection, in vivo photothermal therapy is finally conducted, achieving effective tumor ablation in an animal tumor model. Our study highlights the promise of constructing multifunctional theranostic nanocomposites based on 2D transitional metal dichalcogenides for multimodal imaging-guided cancer therapy.
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影响因子：
16.6
作者：
Chou, Stanley S.;Kaehr, Bryan;Kim, Jaemyung;Foley, Brian M.;De, Mrinmoy;Hopkins, Patrick E.;Huang, Jiaxing;Brinker, C. Jeffrey;Dravid, Vinayak P.
通讯作者：
Dravid, Vinayak P.
影响因子：
82.9
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
17.1
作者：
Hong H;Yang K;Zhang Y;Engle JW;Feng L;Yang Y;Nayak TR;Goel S;Bean J;Theuer CP;Barnhart TE;Liu Z;Cai W
通讯作者：
Cai W
影响因子：
4.9
作者：
Du, Guodong;Guo, Zaiping;Liu, Huakun
通讯作者：
Liu, Huakun
用于磁靶向药物输送、光热疗法和磁共振成像的功能化氧化石墨烯-氧化铁纳米复合材料
影响因子：
9.9
作者：
Ma, Xinxing;Tao, Huiquan;Liu, Zhuang
通讯作者：
Liu, Zhuang