Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey.
Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey.
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DOI：
10.1186/1471-2458-5-66
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发表时间：
2005-06-15
影响因子：
4.5
通讯作者：
Yuksel H
中科院分区：
文献类型：
--
作者：
Ertug S;Okyay P;Turkmen M;Yuksel H
本研究的目的是确定弓形虫病在孕妇怀孕的头三个月的患病率和后续的血清转换为未来两个三个月，并确定风险因素和可能的污染途径在艾丹省，土耳其。样本量计算为423例，患病率为50%，d=0.05，置信水平为95%，添加10%。这是一项多阶段抽样的横断面研究。在对孕妇进行问卷调查后，用ELISA和IFA研究抗弓形虫IgG抗体，与DA试验相冲突的值，其中用ELISA研究IgM抗体，并使用IgM亲和力试验的临界值或阳性值。389例（92.9%）孕妇的平均年龄为24.28 ± 4.56岁，弓形虫IgG抗体阳性率为30.1%。血清阳性率随年龄（p=0.001）和饮用瓶装水以外的水（p=0.042）而增加。抗弓形虫IgG抗体与孕妇的文化程度、本地或外来人口、流产史、食用肉类、蔬菜和奶/奶制品、个人或厨房卫生习惯、家中养猫等无明显关系。未检出IgM抗体。艾丹每三名孕妇中就有一名在怀孕的头三个月有感染弓形虫病的危险。随着年龄的增加血清阳性率是一个可预测的结果，因为增加的时间暴露。随着城市和不受控制的水（井水/泉水）供应的消费，血清阳性率增加与最新的流行病学调查结果相似。
The aims of the present study were to determine the prevalence of toxoplasmosis in pregnant women at first trimester of their pregnancy and to follow up the seroconversion for next two trimesters, and to identify the risk factors and possible contamination routes in Aydin province, Turkey. The sample size was calculated as 423 on a prevalence of 50%, d=0.05 at a confidence level of 95% with 10% addition. It was a cross-sectional study with multistage sampling. After a questionnaire applied to the pregnant women, anti-Toxoplasma IgG antibodies were studied with ELISA and IFA, values in conflict with DA test, where IgM antibodies were studied with ELISA and for borderline or positive values of IgM avidity test was used. The mean age of 389 (92.9%) of pregnant women in the study was 24.28+/-4.56 years, the seroprevalence of anti-Toxoplasma IgG antibodies for toxoplasmosis was 30.1%. Seroprevalence was increased with age (p=0.001) and with drinking water consumption other than bottled water (p=0.042). No significant relations were observed between anti-Toxoplasma IgG antibodies and education level, being native or migrant, abortion history, consumption of meat, vegetable and milk/milk products, personal or kitchen hygiene habits, cat owning at home of the pregnant women. No IgM antibody was detected. One of every three pregnant women in Aydin was at risk of toxoplasmosis at the first trimester of their pregnancy. Increased seroprevalance with age was a predictable result because of increasing time of exposure. Increased seroprevalence with consumption of municipal and uncontrolled water (well/spring water) supplies was similar with latest epidemiological findings.
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影响因子：
4.2
作者：
ADES, AE;PARKER, S;PECKHAM, CS
通讯作者：
PECKHAM, CS
影响因子：
5
作者：
Jones, JL;Kruszon-Moran, D;McAuley, JB
通讯作者：
McAuley, JB
影响因子：
4.2
作者：
Buffolano, W;Gilbert, RE;Ades, AE
通讯作者：
Ades, AE
影响因子：
--
作者：
Cook, AJC;Gilbert, RE;Dunn, DT
通讯作者：
Dunn, DT
影响因子：
1.3
作者：
DUBEY, JP
通讯作者：
DUBEY, JP