Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity.
Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity.
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DOI：
10.1038/s41598-020-72320-z
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发表时间：
2020-09-23
影响因子：
4.6
通讯作者：
Lin CP
中科院分区：
文献类型：
--
作者：
Hung CC;Liu YH;Huang CC;Chou CY;Chen CM;Duann JR;Li CR;Lee TS;Lin CP
氯胺酮一直用于医疗目的，最典型的是作为麻醉剂，最近的研究支持它用于治疗抑郁症。然而，氯胺酮容易被青少年和年轻人滥用。在目前的研究中，我们研究了早期氯胺酮暴露对大脑结构和功能的影响。我们采用核磁共振成像评估氯胺酮滥用对34名使用者和19名非使用者的脑灰质体积（GMV）和功能连接（FC）的影响，采用协变量。根据首次接触氯胺酮的时间，氯胺酮使用者被分为青少年型和成年型。成像数据按照SPM和AFNI中已发表的程序进行处理。结果显示氯胺酮使用者左楔前叶GMV较低，在青少年发病组下降更大。基于种子的相关性分析结果表明，与对照组相比，氯胺酮组左楔前叶（种子）和右楔前叶之间的功能连通性更高。与对照组相比，氯胺酮服用者在右侧脑岛、左侧顶叶下小叶、左侧背外侧前额叶皮层/额上回和左侧内侧眶额叶皮层的GMV均下降。这些初步结果表征了氯胺酮滥用对大脑结构和功能的影响，并强调了早期接触氯胺酮对大脑发育的影响。楔前叶是一种对大脑功能组织至关重要的结构，可能特别容易受到早期氯胺酮暴露的影响。这些大脑结构和功能的变化如何与认知和情感缺陷相关，仍有待大量参与者的确定。
Ketamine has been used for medical purposes, most typically as an anesthetic, and recent studies support its use in the treatment of depression. However, ketamine tends to be abused by adolescents and young adults. In the current study, we examined the effects of early ketamine exposure on brain structure and function. We employed MRI to assess the effects of ketamine abuse on cerebral gray matter volume (GMV) and functional connectivity (FC) in 34 users and 19 non-users, employing covariates. Ketamine users were categorized as adolescent-onset and adult-onset based on when they were first exposed to ketamine. Imaging data were processed by published routines in SPM and AFNI. The results revealed lower GMV in the left precuneus in ketamine users, with a larger decrease in the adolescent-onset group. The results from a seed-based correlation analysis show that both ketamine groups had higher functional connectivity between left precuneus (seed) and right precuneus than the control group. Compared to controls, ketamine users showed decreased GMV in the right insula, left inferior parietal lobule, left dorsolateral prefrontal cortex/superior frontal gyrus, and left medial orbitofrontal cortex. These preliminary results characterize the effects of ketamine misuse on brain structure and function and highlight the influence of earlier exposure to ketamine on the development of the brain. The precuneus, a structure of central importance to cerebral functional organization, may be particularly vulnerable to the influences of early ketamine exposure. How these structural and functional brain changes may relate to the cognitive and affective deficits remains to be determined with a large cohort of participants.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
DOI：
10.1016/j.pnpbp.2011.11.001
发表时间：
2012-07-02
影响因子：
5.6
作者：
Filbey, Francesca M.;DeWitt, Samuel J.
通讯作者：
DeWitt, Samuel J.
DOI：
10.3109/00952990.2015.1049701
发表时间：
2015
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
DeWitt SJ;Ketcherside A;McQueeny TM;Dunlop JP;Filbey FM
通讯作者：
Filbey FM
影响因子：
3.4
作者：
Dahlgren, Mary Kathryn;Sagar, Kelly A.;Gruber, Staci A.
通讯作者：
Gruber, Staci A.
影响因子：
4.5
作者：
Galvez-Buccollini, Juan A.;Proal, Ashley C.;Tomaselli, Veronica;Trachtenberg, Melissa;Coconcea, Cristinel;Chun, Jinsoo;Manschreck, Theo;Fleming, Jerry;Delisi, Lynn E.
通讯作者：
Delisi, Lynn E.