Association between age at onset of psychosis and age at onset of cannabis use in non-affective psychosis.
Association between age at onset of psychosis and age at onset of cannabis use in non-affective psychosis.
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DOI：
10.1016/j.schres.2012.06.007
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发表时间：
2012-08
影响因子：
4.5
通讯作者：
Delisi, Lynn E.
中科院分区：
文献类型：
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作者：
Galvez-Buccollini, Juan A.;Proal, Ashley C.;Tomaselli, Veronica;Trachtenberg, Melissa;Coconcea, Cristinel;Chun, Jinsoo;Manschreck, Theo;Fleming, Jerry;Delisi, Lynn E.
一些研究将大麻使用与精神分裂症的发展联系起来。然而，很难将大麻的影响与其他非法药物的影响区分开来，因为以前的研究没有对纯大麻使用者进行评估。为了测试大麻使用的发作是否对精神病的发生有影响，我们检查了使用和精神病发作之间的时间关系，将我们的分析限制在仅使用大麻而没有其他街头毒品的人群中。57名非情感性精神病患者在患精神病之前使用大麻，使用遗传研究诊断访谈（DIGS）进行了访谈。遗传学研究的家庭访谈（FIGS）也被用来采访一个家庭线人的精神疾病的病人和整个家庭。多元线性回归技术被用来估计变量之间的关联。在调整了性别、年龄、酒精滥用或依赖的终生诊断以及精神分裂症家族史等潜在混杂因素后，大麻发作年龄与精神病发作年龄显著相关（β = 0.4，95% CI = 0.1 - 0.7，p = 0.004）和首次住院时的年龄（β = 0.4，95% CI = 0.1 - 0.8，p = 0.008）。开始使用大麻和精神病发作之间的平均时间为7.0 ± 4.3。开始饮酒时的年龄与精神病发作时的年龄或首次住院时的年龄无关。大麻的发病年龄与精神病发病年龄和首次住院年龄直接相关。在调整潜在的混杂因素后，这些关联仍然显着，并且与大麻可能导致或沉淀精神病发作的假设一致。
Several studies have associated cannabis use with the development of schizophrenia. However, it has been difficult to disentangle the effects of cannabis from that of other illicit drugs, as previous studies have not evaluated pure cannabis users. To test whether the onset of cannabis use had an effect on the initiation of psychosis, we examined the time relationship between onset of use and onset of psychosis, restricting our analysis to a cohort of individuals who only used cannabis and no other street drugs. Fifty seven subjects with non-affective psychoses who used cannabis prior to developing a psychosis were interviewed using the Diagnostic Interview for Genetic Studies (DIGS). The Family Interview for Genetic Studies (FIGS) was also used to interview a family informant about psychiatric illness in the patient and the entire family. Multiple linear regression techniques were used to estimate the association between variables. After adjusting for potential confounding factors such as sex, age, lifetime diagnosis of alcohol abuse or dependence, and family history of schizophrenia, the age at onset of cannabis was significantly associated with age at onset of psychosis (β=0.4, 95% CI=0.1–0.7, p=0.004) and age at first hospitalization (β=0.4, 95% CI=0.1–0.8, p=0.008). The mean time between beginning to use cannabis and onset of psychosis was 7.0±4.3. Age at onset of alcohol use was not associated with age at onset of psychosis or age at first hospitalization. Age at onset of cannabis is directly associated with age at onset of psychosis and age at first hospitalization. These associations remain significant after adjusting for potential confounding factors and are consistent with the hypothesis that cannabis could cause or precipitate the onset of psychosis after a prolonged period of time.
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影响因子：
--
作者：
Zammit, S;Allebeck, P;Lewis, G
通讯作者：
Lewis, G
DOI：
10.1177/070674371005500308
发表时间：
2010-03-01
影响因子：
4
作者：
Dragt, Sara;Nieman, Dorien H.;Linszen, Don H.
通讯作者：
Linszen, Don H.
影响因子：
10.5
作者：
Barnett, Jennifer H.;Werners, Ursula;Jones, Peter B.
通讯作者：
Jones, Peter B.
影响因子：
10.5
作者：
Barnes, TRE;Mutsatsa, SH;Joyce, EM
通讯作者：
Joyce, EM
影响因子：
6.7
作者：
Estrada, G.;Fatjo-Vilas, M.;Fananas, L.
通讯作者：
Fananas, L.