Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.
Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.
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DOI：
10.1016/j.jcv.2011.06.022
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发表时间：
2011-10
影响因子：
8.8
通讯作者：
Cowling, Benjamin J.
中科院分区：
文献类型：
--
作者：
Poon, Leo L. M.;Chan, Kowk H.;Chu, Daniel K. W.;Fung, Cherry C. Y.;Cheng, Calvin K. Y.;Ip, Dennis K. M.;Leung, Gabriel M.;Peiris, Joseph S. M.;Cowling, Benjamin J.
文献中关于宿主世代/连续传播事件之间病毒序列变异的数据很少。对于家庭内传播的流感病毒的序列异质性知之甚少。研究流感病毒的分子流行病学，并确定 2009 年第一波流感大流行期间个人、家庭和社区内的序列变异。在 2009 年流感大流行期间，对香港甲型流感家庭传播进行了前瞻性研究。对本次家庭传播研究中发现的大流行性和季节性甲型流感病毒分离株的 HA 和 NA 序列进行了测序和分析。我们的研究结果显示，流感病毒多次传入香港。对这些分离株的序列分析表明，这些家庭群的成员是通过家庭传播获得感染的。有趣的是，与之前的家庭传播研究得出的结论不同，我们观察到同一个人以及同一家庭内的连续样本之间存在序列差异。甲型流感病毒家庭聚集性感染主要是家庭内二次传播的结果。我们的结果还表明，宿主内病毒序列变异可能比之前想象的更为常见。
There are few data in the literature on viral sequence variation between host generations/successive transmission events. Relatively little is known about the sequence heterogeneity of the influenza viruses transmitted within families. To study the molecular epidemiology of influenza virus and to determine the sequence variation within an individual, a household and a community during the first wave of influenza pandemic in 2009. A prospective study of household transmission of influenza A in Hong Kong was conducted during the pandemic in 2009. The HA and NA sequences of pandemic and seasonal influenza A viral isolates identified in this household transmission study were sequences and analyzed. Our results indicated that there were multiple introductions of influenza viruses into Hong Kong. Sequence analysis of these isolates suggested that members of these family clusters acquired the infection by household transmissions. Interestingly, unlike those concluded from previous household transmission studies, we observed sequence variations between sequential samples from the same person and also within the same household. Family clusters of influenza A viral infection are predominantly the result of secondary transmission within a household. Our results also suggested that the intra-host viral sequence variation might be more common that than previously thought.
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影响因子：
3.7
作者：
Potdar VA;Chadha MS;Jadhav SM;Mullick J;Cherian SS;Mishra AC
通讯作者：
Mishra AC
DOI：
10.1126/science.1189132
发表时间：
2010-06-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Vijaykrishna D;Poon LL;Zhu HC;Ma SK;Li OT;Cheung CL;Smith GJ;Peiris JS;Guan Y
通讯作者：
Guan Y
影响因子：
11.8
作者：
Wu JT;Cowling BJ;Lau EH;Ip DK;Ho LM;Tsang T;Chuang SK;Leung PY;Lo SV;Liu SH;Riley S
通讯作者：
Riley S
影响因子：
3.6
作者：
Teo, Stephen S. S.;Ellis, Joanna S.;Booy, Robert
通讯作者：
Booy, Robert
影响因子：
3.7
作者：
Shiino T;Okabe N;Yasui Y;Sunagawa T;Ujike M;Obuchi M;Kishida N;Xu H;Takashita E;Anraku A;Ito R;Doi T;Ejima M;Sugawara H;Horikawa H;Yamazaki S;Kato Y;Oguchi A;Fujita N;Odagiri T;Tashiro M;Watanabe H
通讯作者：
Watanabe H