Meal-Induced Symptoms in Children with Dyspepsia-Relationships to Sex and the Presence of Gastroparesis.
Meal-Induced Symptoms in Children with Dyspepsia-Relationships to Sex and the Presence of Gastroparesis.
复制标题
DOI：
10.1016/j.jpeds.2020.12.048
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Shulman RJ
中科院分区：
文献类型：
--
作者：
Febo-Rodriguez L;Chumpitazi BP;Musaad S;Sher AC;Shulman RJ
为了检验以下假设：在消化不良儿童中，进食后的预期症状严重程度与胃潴留百分比相关，最终诊断为胃轻瘫的儿童会报告更严重的症状。前瞻性单中心研究，104名消化不良儿童在胃排空造影（GES）期间进食标准Tougas餐前后完成前瞻性消化不良症状问卷。主要结果包括胃潴留与症状的相关性以及有和无胃轻瘫的患者之间症状严重程度的比较。胃轻瘫患儿52例（50%）（胃轻瘫患儿12.5 ± 2.9岁，女性65%;非胃轻瘫患儿13.0 ± 2.9岁，女性60%; P均>0.05）。腹胀是唯一的症状显着恶化青年胃轻瘫。对于整个队列，腹胀和饱胀与保留百分比相关。然而，在胃轻瘫患者中，只有恶心与尿潴留相关（4小时; rs=0.275，P<0.05）。女生胃轻瘫症状（除饱腹感外）明显差于男生（P<0.05）。总体而言，根据现行标准，胃轻瘫儿童与正常排空儿童之间的症状严重程度差异不大。然而，与胃轻瘫男孩相比，胃轻瘫女孩的症状更严重，强调需要进一步研究性别在胃轻瘫症状中的作用。在所有儿童中，腹胀和饱胀与胃潴留适度相关，恶心与胃轻瘫相关。
To test the hypothesis that in dyspeptic children, prospective symptom severity following ingestion of a meal would correlate with percent gastric retention, and those ultimately diagnosed with gastroparesis would report worse symptoms. Prospective, single center study with 104 children with dyspepsia completing a prospective dyspepsia symptom questionnaire before and after eating a standardized Tougas meal during gastric emptying scintigraphy (GES). Main outcomes included correlation between gastric retention and symptoms and comparison of symptom severity between those with and without gastroparesis. 52 children (50%) had gastroparesis (gastroparesis: 12.5 ± 2.9 years, 65% female; non-gastroparesis: 13.0 ± 2.9 years, 60% female; all P>0.05). Bloating was the only symptom significantly worse in youth with gastroparesis. For the entire cohort, bloating and fullness correlated with percent retention. However, in those with gastroparesis, only nausea correlated with retention (4 hr.; rs=0.275, P< .05). Girls with gastroparesis had significantly worse symptoms (except satiety) when compared with boys with gastroparesis (P<0.05). Overall in children, there is little difference in symptom severity between children with gastroparesis vs. normal emptying based on current standards. However, girls with gastroparesis have worse symptoms vs. boys with gastroparesis, underscoring a need for further studies into the role of sex in gastroparesis symptoms. In all children, both bloating and fullness correlated modestly with gastric retention, and nausea correlated in those with gastroparesis.
登录
查看更多内容
影响因子：
5.2
作者：
Cassidy RM;Tong Q
通讯作者：
Tong Q
影响因子：
29.4
作者：
Parkman HP;Yates K;Hasler WL;Nguyen L;Pasricha PJ;Snape WJ;Farrugia G;Koch KL;Abell TL;McCallum RW;Lee L;Unalp-Arida A;Tonascia J;Hamilton F;National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
通讯作者：
National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
影响因子：
3.5
作者：
Shahsavari, Dariush;Yu, Daohai;Parkman, Henry P.
通讯作者：
Parkman, Henry P.
影响因子：
81.5
作者：
Camilleri, Michael;Chedid, Victor;Stanghellini, Vincenzo
通讯作者：
Stanghellini, Vincenzo
影响因子：
5.1
作者：
Wong, Gregory K.;Shulman, Robert J.;Chumpitazi, Bruno P.
通讯作者：
Chumpitazi, Bruno P.