Dynamic changes in brain structure in patients with post-traumatic stress disorder after motor vehicle accident: A voxel-based morphometry-based follow-up study.
Dynamic changes in brain structure in patients with post-traumatic stress disorder after motor vehicle accident: A voxel-based morphometry-based follow-up study.
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机动车事故后创伤后应激障碍患者大脑结构的动态变化：基于体素的形态测量随访研究
DOI：
10.3389/fpsyg.2022.1018276
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发表时间：
2022
影响因子：
3.8
通讯作者：
Liu, Chaomeng
中科院分区：
文献类型：
--
作者：
Yang, Luodong;Li, Haohao;Meng, Yao;Shi, Yan;Ge, Anxin;Zhang, Guiqing;Liu, Chaomeng
目的探讨创伤后应激障碍（PTSD）患者和创伤暴露者经历车祸后情绪和记忆相关脑区的动态变化。收集创伤后2天内发生MVA的患者的功能磁共振成像（fMRI）和一般资料，并评估其社会支持和应对方式。精神障碍诊断和统计手册第五版（PCL-5）的PTSD检查表用于筛查和诊断。随后，17名PTSD患者和23名车祸创伤暴露者在2个月后完成了第二次fMRI扫描。采用基于体素的形态计量学（VBM）分析数据，以检查相关脑区的体积变化。相关分析用于评估感兴趣区（ROI）与临床量表总分之间的相关性。随后，研究SCL-5总分与简易应对方式问卷（SCSQ）和社会支持量表（SSRS）的个体维度之间的关系。与对照组相比，结果显示PTSD组在2个月时右侧SFG体积减少。同样，PTSD组内的比较显示，在2个月时左STG体积减少。与对照组相比，PTSD患者的应对方式更消极，客观支持和主观支持的表现更差。此外，PCL-5总分与积极应对、客观支持和主观支持呈负相关。PTSD的发生可能与右SFG和左STG的体积减少有关，PTSD患者接受的社会支持较少，在面对压力事件时倾向于以消极的方式科普。这些结果表明，在MVA的2个月内，患有PTSD的人的某些大脑区域发生了灰质体积的变化。我们相信，我们的研究结果将提供有用的洞察创伤后应激障碍的神经心理机制。
To investigate the dynamic changes of emotional and memory-related brain regions in post-traumatic stress disorder (PTSD) patients and trauma-exposed subjects, who experienced motor vehicle accident (MVA). Functional Magnetic Resonance imaging (fMRI) and general data were collected from trauma victims who had experienced MVA within 2 days, and their social support and coping style were evaluated. The PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PCL-5) is used for screening and diagnosis. Subsequently, 17 PTSD patients and 23 car accident trauma-exposed individuals completed a second fMRI scan at 2 months. Data were analyzed by using voxel-based morphometry (VBM) to examine the volume changes of relevant brain regions. Correlation analysis was used to assess the correlation between the regions of interest (ROIs) and the total scores on the clinical scales. Subsequently, the relationship between the total PCL-5 scores and the individual dimensions of the Simplified Coping Style Questionnaire (SCSQ) and the Social Support Rate Scale (SSRS) was studied. In comparison with the control group, the results showed a reduction in right SFG volume in the PTSD group at 2 months. Similarly, a comparison within the PTSD group revealed a reduction in the left STG volume at 2 months. Compared with the control group, PTSD patients showed a more negative coping style and worse performance in objective and subjective support. In addition, the total PCL-5 scores were negatively associated with positive coping, objective support, and subjective support. The occurrence of PTSD may be related to reduced volume of the right SFG and left STG, and that patients with PTSD receive less social support and tend to cope in a negative manner in the face of stressful events. These results suggest that within 2 months of the MVA, changes in gray matter volume have occurred in some brain regions of those suffering from PTSD. We believe the results of our study will provide useful insights into the neuropsychological mechanisms underlying PTSD.
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