Roles and regulation of gastrointestinal eosinophils in immunity and disease.
Roles and regulation of gastrointestinal eosinophils in immunity and disease.
复制标题
胃肠道嗜酸性粒细胞在免疫和疾病中的作用和调节。
DOI：
10.4049/jimmunol.1400413
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发表时间：
2014-08-01
期刊：
影响因子：
--
通讯作者：
Rothenberg ME
中科院分区：
文献类型：
--
作者：
Jung Y;Rothenberg ME
嗜酸性粒细胞被认为是破坏性的终末期效应细胞，其通过释放其颗粒衍生的细胞毒性蛋白在寄生虫感染和变态反应中起作用。然而，越来越多的实验观察表明，嗜酸性粒细胞也是多功能的白细胞参与各种炎症和生理免疫反应。在体内平衡条件下，嗜酸性粒细胞在胃肠道固有层中特别丰富，其中它们参与胃肠道内的各种生物过程。在这篇综述中，我们总结了嗜酸性粒细胞发展的分子步骤，并描述嗜酸性粒细胞贩运到胃肠道。我们综合目前的研究结果，胃肠道嗜酸性粒细胞的表型和功能特性和积累的证据表明，他们在胃肠道疾病的贡献作用，重点是原发性嗜酸性胃肠道疾病。最后，我们讨论了嗜酸性粒细胞作为肠道免疫系统调节剂的潜在作用。
Eosinophils have been considered to be destructive end-stage effector cells that have a role in parasitic infections and allergy reactions by the release of their granule-derived cytotoxic proteins. However, an increasing number of experimental observations indicate that eosinophils also are multifunctional leukocytes involved in diverse inflammatory and physiologic immune responses. Under homeostatic conditions, eosinophils are particularly abundant in the lamina propria of the gastrointestinal tract where their involvement in various biological processes within the gastrointestinal tract has been posited. In this review, we summarize the molecular steps involved in eosinophil development and describe eosinophil trafficking to the gastrointestinal tract. We synthesize the current findings on the phenotypic and functional properties of gastrointestinal eosinophils and the accumulating evidence that they have a contributory role in gastrointestinal disorders, with a focus on primary eosinophilic gastrointestinal disorders. Finally, we discuss the potential role of eosinophils as modulators of the intestinal immune system.
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影响因子：
30.5
作者：
Ben Baruch-Morgenstern, Netali;Shik, Dana;Moshkovits, Itay;Itan, Michal;Karo-Atar, Danielle;Bouffi, Carine;Fulkerson, Patricia C.;Rashkovan, Diana;Jung, Steffen;Rothenberg, Marc E.;Munitz, Ariel
通讯作者：
Munitz, Ariel
影响因子：
4.4
作者：
Forbes, E;Murase, T;Hogan, SP
通讯作者：
Hogan, SP
DOI：
10.1084/jem.183.5.2349
发表时间：
1996-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Daugherty BL;Siciliano SJ;DeMartino JA;Malkowitz L;Sirotina A;Springer MS
通讯作者：
Springer MS
影响因子：
9.8
作者：
Bischoff, SC;Mayer, J;Manns, MP
通讯作者：
Manns, MP
DOI：
10.1016/j.bpg.2007.10.023
发表时间：
2008-01-01
影响因子：
3.2
作者：
Fulkerson, Patricia C.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.