A multimodal imaging approach to the evaluation of post-traumatic epilepsy.
A multimodal imaging approach to the evaluation of post-traumatic epilepsy.
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DOI：
10.1007/s10334-012-0316-9
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发表时间：
2012-10
影响因子：
2.3
通讯作者：
Manganotti, Paolo
中科院分区：
文献类型：
--
作者：
Storti, Silvia F.;Formaggio, Emanuela;Franchini, Enrica;Bongiovanni, Luigi G.;Cerini, Roberto;Fiaschi, Antonio;Michel, Christoph M.;Manganotti, Paolo
脑电图-功能磁共振成像（EEG-fMRI）共配准和高密度脑电图（hdEEG）可以结合起来，非侵入性的异常脑激活癫痫过程引起的地图。通过结合非侵入性成像技术在多模式的方法，我们试图调查癫痫活动的病理生理机制在7例严重创伤性脑损伤患者。标准EEG和fMRI数据在单次扫描期间采集。采用一般线性模型和独立成分分析对脑电功能磁共振成像数据进行分析。采用256通道高分辨脑电图对发作间期癫痫样放电（IEDs）进行源性定位。然后将血氧水平依赖（BOLD）定位与EEG源重建进行比较。在hdEEG上，所有7名患者均检测到局灶源定位; 7名患者中有6名与EEG数据和临床评价定义的预期癫痫活动一致; 7名记录IED的患者中有4名观察到BOLD信号变化。这些活动与源定位部分一致。多模式整合的EEG-fMRI和hdEEG结合两种不同的方法来定位相同的癫痫灶似乎是一个很有前途的工具，非侵入性地图异常脑激活的创伤后脑损伤患者。
Electroencephalography-functional magnetic resonance imaging (EEG-fMRI) coregistration and high-density EEG (hdEEG) can be combined to map noninvasively abnormal brain activation elicited by epileptic processes. By combining noninvasive imaging techniques in a multimodal approach, we sought to investigate pathophysiological mechanisms underlying epileptic activity in seven patients with severe traumatic brain injury. Standard EEG and fMRI data were acquired during a single scanning session. The EEG-fMRI data were analyzed using the general linear model and independent component analysis. Source localization of interictal epileptiform discharges (IEDs) was performed using 256-channel hdEEG. Blood oxygenation level dependent (BOLD) localizations were then compared to EEG source reconstruction. On hdEEG, focal source localization was detected in all seven patients; in six out of seven it was concordant with the expected epileptic activity as defined by EEG data and clinical evaluation; and in four out of seven in whom IEDs were recorded, BOLD signal changes were observed. These activities were partially concordant with the source localization. Multimodal integration of EEG-fMRI and hdEEG combining two different methods to localize the same epileptic foci appears to be a promising tool to noninvasively map abnormal brain activation in patients with post-traumatic brain injury.
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