Theoretical analysis of the local field potential in deep brain stimulation applications.
Theoretical analysis of the local field potential in deep brain stimulation applications.
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DOI：
10.1371/journal.pone.0059839
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
McIntyre CC
中科院分区：
文献类型：
--
作者：
Lempka SF;McIntyre CC
脑深部电刺激（DBS）是治疗帕金森病（PD）等运动障碍的常用疗法，为研究人类患者各种皮层下结构的神经活动提供了独特的机会。局部场电位（LFP）记录通常通过术中微电极或DBS导线进行，反映基底神经节核内的振荡活动。这些LFP记录具有许多临床意义，有朝一日可能用于优化闭环系统中的DBS结果。然而，对记录的LFP的起源了解甚少。因此，本研究的目的是在临床DBS应用的背景下对LFP记录进行理论分析。这一目标是通过丘脑下核β振荡（~ 20 Hz）的详细记录模型实现的。记录模型由术中植入脑内微电极和DBS大电极的有限元模型以及STN投射神经元的多室索模型组成。模型分析允许系统地调查可能影响记录的LFP组成的许多变量（例如电极尺寸，电极阻抗，记录配置，大脑的过滤效果，电极-电解质界面和记录电子）。研究结果表明，LFP的空间范围可以扩大几毫米。模型分析还表明，电极几何形状和记录配置等变量对LFP振幅和空间范围有显著影响，而电极阻抗等其他变量的影响通常可以忽略不计。本研究的结果为LFP的起源提供了深入的了解，并确定了在临床DBS应用中分析LFP记录时需要考虑的变量。
Deep brain stimulation (DBS) is a common therapy for treating movement disorders, such as Parkinson’s disease (PD), and provides a unique opportunity to study the neural activity of various subcortical structures in human patients. Local field potential (LFP) recordings are often performed with either intraoperative microelectrodes or DBS leads and reflect oscillatory activity within nuclei of the basal ganglia. These LFP recordings have numerous clinical implications and might someday be used to optimize DBS outcomes in closed-loop systems. However, the origin of the recorded LFP is poorly understood. Therefore, the goal of this study was to theoretically analyze LFP recordings within the context of clinical DBS applications. This goal was achieved with a detailed recording model of beta oscillations (∼20 Hz) in the subthalamic nucleus. The recording model consisted of finite element models of intraoperative microelectrodes and DBS macroelectrodes implanted in the brain along with multi-compartment cable models of STN projection neurons. Model analysis permitted systematic investigation into a number of variables that can affect the composition of the recorded LFP (e.g. electrode size, electrode impedance, recording configuration, and filtering effects of the brain, electrode-electrolyte interface, and recording electronics). The results of the study suggest that the spatial reach of the LFP can extend several millimeters. Model analysis also showed that variables such as electrode geometry and recording configuration can have a significant effect on LFP amplitude and spatial reach, while the effects of other variables, such as electrode impedance, are often negligible. The results of this study provide insight into the origin of the LFP and identify variables that need to be considered when analyzing LFP recordings in clinical DBS applications.
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影响因子：
16.2
作者：
Kajikawa Y;Schroeder CE
通讯作者：
Schroeder CE
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4
作者：
Lempka SF;Miocinovic S;Johnson MD;Vitek JL;McIntyre CC
通讯作者：
McIntyre CC
影响因子：
16.2
作者：
Kreiman, G;Hung, CP;DiCarlo, JJ
通讯作者：
DiCarlo, JJ
影响因子：
14.5
作者：
Kühn, AA;Williams, D;Brown, P
通讯作者：
Brown, P