Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community.
Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community.
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DOI：
10.1016/j.envres.2012.05.005
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发表时间：
2012-08
影响因子：
8.3
通讯作者：
Holland, Nina
中科院分区：
文献类型：
--
作者：
Huen, Karen;Bradman, Asa;Harley, Kim;Yousefi, Paul;Barr, Dana Boyd;Eskenazi, Brenda;Holland, Nina
有机磷农药被广泛使用，最近的研究表明，宫内暴露与不良生育结局和神经发育有关。很少有研究表征人体血浆中的有机磷农药，或确定这些水平与尿液测量的相关性。为了比较两种生物基质中有机磷农药代谢产物的水平，我们测定了居住在农业区的受试者母体尿液中的有机磷农药代谢物，以及母体和脐带血中的毒死蜱和二氮磷。我们还检测了母亲及其新生儿的对氧磷酶1(PON1)基因类型(PON1192和PON1-108)和PON1底物特异性活性，以检查PON1是否会影响血液和尿液中有机磷农药的测定。孕妇和脐带血样中毒死蜱血药浓度分别为70.5%和87.5%，血药浓度范围为0~1726 ng/mL。二氮磷水平较低(0~0.5 ng/mL)，33.3%的母血和47.3%的脐血中存在非零值。血液中的有机磷农药水平和尿液中的代谢物水平之间的显著关联仅限于对PON1水平进行调整的模型。母亲PON1水平的增加与毒死蜱和二氮磷检测的几率降低相关(优势比(OR)分别为0.56和0.75)。研究参与者的血液中有机磷农药水平在母亲和新生儿中相似，略高于其他人群中报告的水平。然而，与他们的母亲相比，新生儿的PON1解毒酶的数量要少得多，这表明婴儿可能特别容易受到有机磷农药的影响。
Organophosphate pesticides are widely used and recent studies suggest associations of in utero exposures with adverse birth outcomes and neurodevelopment. Few studies have characterized organophosphate pesticides in human plasma or established how these levels correlate to urinary measurements. We measured organophosphate pesticide metabolites in maternal urine and chlorpyrifos and diazinon in maternal and cord plasma of subjects living in an agricultural area to compare levels in two different biological matrices. We also determined paraoxonase 1 (PON1) genotypes (PON1192 and PON1-108) and PON1 substrate-specific activities in mothers and their newborns to examine whether PON1 may affect organophosphate pesticide measurements in blood and urine. Chlorpyrifos levels in plasma ranged from 0-1726 ng/mL and non-zero levels were measured in 70.5% and 87.5% of maternal and cord samples, respectively. Diazinon levels were lower (0-0.5 ng/mL); non-zero levels were found in 33.3% of maternal plasma and 47.3% of cord plasma. Significant associations between organophosphate pesticide levels in blood and metabolite levels in urine were limited to models adjusting for PON1 levels. Increased maternal PON1 levels were associated with decreased odds of chlorpyrifos and diazinon detection (odds ratio(OR): 0.56 and 0.75, respectively). Blood organophosphate pesticide levels of study participants were similar in mothers and newborns and slightly higher than those reported in other populations. However, compared to their mothers, newborns have much lower quantities of the detoxifying PON1 enzyme suggesting that infants may be especially vulnerable to organophosphate pesticide exposures.
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影响因子：
10.4
作者：
Eskenazi, Brenda;Marks, Amy R.;Bradman, Asa;Harley, Kim;Barr, Dana B.;Johnson, Caroline;Morga, Norma;Jewell, Nicholas A.
通讯作者：
Jewell, Nicholas A.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
2.5
作者：
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通讯作者：
Barr, DB