Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence.
Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence.
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DOI：
10.1016/j.biopsych.2008.05.027
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发表时间：
2008-10-15
影响因子：
10.6
通讯作者：
Stein MB
中科院分区：
文献类型：
--
作者：
Simmons AN;Paulus MP;Thorp SR;Matthews SC;Norman SB;Stein MB
亲密伴侣暴力（IPV）是女性创伤后应激障碍（PTSD）的最常见原因之一。 IPV 的受害者常常全神贯注于对即将发生的伤害的预期。这项调查检验了这样的假设：IPV 相关的 PTSD 个体对厌恶刺激的预期表现出过度的岛叶反应。 15 名有 IPV 病史并继发 PTSD (IPV-PTSD) 的女性和 15 名未受创伤的对照 (NTC) 女性执行了一项任务，其中包括在功能磁共振成像期间对积极和消极事件的图像进行暗示预期。在预期负图像减去预期正图像期间，两组均显示出双侧前岛叶的激活增加。相对于 NTC 组，IPV-PTSD 组右前/中岛叶的激活明显更强。功能连接分析显示，与 IPV-PTSD 受试者相比，NTC 中右中岛叶和双侧前岛叶的激活变化与杏仁核激活变化的相关性更强。患有 IPV 相关 PTSD 的女性在消极预期期间前/中岛叶的激活增加。患有 IPV 的女性的这些发现可能是 IPV 暴露的结果，反映了先前存在的岛叶功能差异，或者是由于 PTSD 的发展。因此，未来的纵向研究需要检验这些可能性。
Intimate partner violence (IPV) is one of the most common causes of posttraumatic stress disorder (PTSD) in women. Victims of IPV are often preoccupied by the anticipation of impending harm. This investigation tested the hypothesis that IPV-related PTSD individuals show exaggerated insula reactivity to the anticipation of aversive stimuli. Fifteen women with a history of IPV and consequent PTSD (IPV-PTSD) and 15 non-traumatized control (NTC) women performed a task involving cued anticipation to images of positive and negative events during functional magnetic resonance imaging. Both groups showed increased activation of bilateral anterior insula during anticipation of negative images minus anticipation of positive images. Activation in right anterior/middle insula was significantly greater in the IPV-PTSD relative to the NTC group. Functional connectivity analysis revealed that changes in activation in right middle insula and bilateral anterior insula were more strongly associated with amygdala activation changes in NTC than in IPV-PTSD subjects. Increased activation in the anterior/middle insula during negative anticipation in women with IPV-related PTSD. These findings in women with IPV could be a consequence of the IPV exposure, reflect pre-existing differences in insular function, or due to the development of PTSD. Thus, future longitudinal studi4s need to examine these possibilities.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Chua, P;Krams, M;Dolan, R
通讯作者：
Dolan, R
影响因子：
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作者：
Geuze, Elbert;Westenberg, Herman G. M.;Schmahl, Christian
通讯作者：
Schmahl, Christian
影响因子：
4.6
作者：
Breslau, Naomi;Anthony, James C.
通讯作者：
Anthony, James C.
影响因子：
2.5
作者：
Critchley, HD
通讯作者：
Critchley, HD