Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.
Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.
复制标题
DOI：
10.1038/s41467-022-28859-8
复制
发表时间：
2022-03-22
影响因子：
16.6
通讯作者：
Birbaumer N
中科院分区：
文献类型：
--
作者：
Chaudhary U;Vlachos I;Zimmermann JB;Espinosa A;Tonin A;Jaramillo-Gonzalez A;Khalili-Ardali M;Topka H;Lehmberg J;Friehs GM;Woodtli A;Donoghue JP;Birbaumer N
随着运动神经元变性的进展，肌萎缩侧索硬化症(ALS)患者可能失去所有以肌肉为基础的沟通途径，最终他们可能失去任何沟通手段。虽然其他人评估了仍有肌肉控制力的人的沟通，但就我们所知，尚不清楚在完全锁定的状态下，基于神经的沟通是否仍有可能。在这里，我们将两个微电极阵列植入了一名完全锁定状态的肌萎缩侧索硬化症患者的辅助和初级运动皮质。患者根据听觉反馈调节神经放电频率，并使用这一策略一次选择一个字母来形成单词和短语，以交流他的需求和经验。这个案例研究提供了证据，证明即使在完全锁定的状态下，基于大脑的意志交流也是可能的。作者记录了一名处于完全锁定状态的肌萎缩侧索硬化症患者的神经放电速率，并表明患者可以根据听觉反馈调节神经放电速率，以选择字母组成单词和短语，以交流他的需求和经历。
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state. The authors record neural firing rates in a patient with ALS in completely locked-in state and show that the patient can modulate neural firing rates based on auditory feedback to select letters to form words and phrases to communicate his needs and experiences.
登录
查看更多内容
影响因子：
17.1
作者：
Jarosiewicz B;Sarma AA;Bacher D;Masse NY;Simeral JD;Sorice B;Oakley EM;Blabe C;Pandarinath C;Gilja V;Cash SS;Eskandar EN;Friehs G;Henderson JM;Shenoy KV;Donoghue JP;Hochberg LR
通讯作者：
Hochberg LR
DOI：
10.1016/j.clinph.2008.06.019
发表时间：
2008-11
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Kübler A;Birbaumer N
通讯作者：
Birbaumer N
影响因子：
3.4
作者：
CHOU, SM;NORRIS, FH
通讯作者：
NORRIS, FH
影响因子：
9.9
作者：
Kübler, A;Nijboer, F;Wolpaw, JR
通讯作者：
Wolpaw, JR
影响因子：
64.8
作者：
Hochberg, Leigh R.;Serruya, Mijail D.;Donoghue, John P.
通讯作者：
Donoghue, John P.