Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure.
Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure.
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超越成人海马中的新神经元：丙咪嗪作为一种促星形胶质细胞生成因子，可挽救因压力暴露引起的认知障碍。
DOI：
10.3390/cells11030390
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发表时间：
2022-01-24
期刊：
影响因子：
6
通讯作者：
Pinto L
中科院分区：
文献类型：
--
作者：
Machado-Santos AR;Loureiro-Campos E;Patrício P;Araújo B;Alves ND;Mateus-Pinheiro A;Correia JS;Morais M;Bessa JM;Sousa N;Rodrigues AJ;Oliveira JF;Pinto L
抑郁症是一种普遍存在的社会负担性疾病。不同的研究表明星形胶质细胞作为神经传递和神经血管耦合的调节剂在抑郁症的病理生理中起着重要的作用。在抑郁症患者的大脑中观察到星形胶质细胞损伤，以及在动物模型中星形胶质细胞功能障碍后出现抑郁样行为，都证明了这一点。然而，人们对哺乳动物大脑中新生星形胶质细胞的重要性知之甚少，特别是它可能参与抑郁症的沉淀和当前抗抑郁药（ADs）的治疗作用。因此，我们研究了暴露于不可预测的慢性轻度应激（uCMS）方案的大鼠海马齿状回（DG）中星形胶质细胞和成年星形胶质细胞形成的调节，未经治疗并使用抗抑郁药氟西汀和丙咪嗪治疗两周。我们的研究结果表明，应激和丙咪嗪可调节DG中成人星形胶质细胞的形成。本研究揭示了不同类型的ad对星形胶质细胞形成过程的影响不同，显示了不同的细胞机制与慢性应激暴露引起的行为缺陷的恢复有关。因此，除了那些常驻的星形胶质细胞外，海马DG中的新生星形胶质细胞也可能是未来神经精神领域治疗的有希望的治疗靶点。
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
星形胶质细胞钙高程的功能作用：从突触到行为。
影响因子：
5.3
作者：
Guerra-Gomes S;Sousa N;Pinto L;Oliveira JF
通讯作者：
Oliveira JF
DOI：
10.1002/neu.1043
发表时间：
2001-08-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Gensert, JM;Goldman, JE
通讯作者：
Goldman, JE
影响因子：
23.9
作者：
Encinas, Juan M.;Michurina, Tatyana V.;Peunova, Natalia;Park, June-Hee;Tordo, Julie;Peterson, Daniel A.;Fishell, Gord;Koulakov, Alex;Enikolopov, Grigori
通讯作者：
Enikolopov, Grigori
DOI：
10.3390/molecules16097980
发表时间：
2011-09-15
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Cavanagh BL;Walker T;Norazit A;Meedeniya AC
通讯作者：
Meedeniya AC