Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives.
Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives.
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DOI：
10.1039/c0nr00485e
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发表时间：
2011-02
期刊：
影响因子：
6.7
通讯作者：
Nanci A
中科院分区：
文献类型：
--
作者：
Variola F;Brunski JB;Orsini G;Tambasco de Oliveira P;Wazen R;Nanci A
纳米级表面特性刺激和引导植入物/组织界面处的各种分子和生物过程的证据正在培育植入式金属设计的新趋势。来自广泛不同领域（例如纳米技术、材料工程和生物学）的尖端专业知识和技术已被有利地用于纳米工程表面，以可预测的方式控制和指导这些过程。在这篇综述中，我们介绍并讨论了目前用于修饰骨科和牙科应用金属表面的基于纳米技术的最先进方法，并简要考虑了它们在心血管领域的应用。首先讨论了纳米工程表面对各种体外分子和细胞事件的影响。重要的是，这篇综述还概述了纳米结构金属植入物的体内和临床研究，并讨论了纳米形貌对界面生物力学事件的潜在影响。这项工作的最终目标是让读者全面了解无穷小在生物医学表面科学应用中的当前进展、未来发展和挑战。我们相信，为了正确利用纳米结构可植入金属，事实上，所有生物材料，必须对体外行为，特别是体内行为有一个全面的了解。
Evidence that nanoscale surface properties stimulate and guide various molecular and biological processes at the implant/tissue interface is fostering a new trend in designing implantable metals. Cutting-edge expertise and techniques drawn from widely separated fields, such as nanotechnology, materials engineering and biology, have been advantageously exploited to nanoengineer surfaces in ways that control and direct these processes in predictable manners. In this review, we present and discuss the state-of-the-art of nanotechnology-based approaches currently used to modify the surface of metals used for orthopedic and dental applications, and also briefly consider their use in the cardiovascular field. The effects of nanoengineered surfaces on various in vitro molecular and cellular events are firstly discussed. Importantly, this review also provides an overview of in vivo and clinical studies with nanostructured metallic implants, and addresses the potential influence of nanotopography on biomechanical events at interfaces. Ultimately the objective of this work is to give the readership a comprehensive picture of the current advances, future developments and challenges in the application of the infinitesimally small to biomedical surface science. We believe that an integrated understanding of the in vitro and particularly of the in vivo behavior is mandatory for the proper exploitation of nanostructured implantable metals and, as a matter of fact, all biomaterials.
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影响因子：
3.2
作者：
Auernheimer, J;Zukowski, D;Kessler, H
通讯作者：
Kessler, H
影响因子：
5.4
作者：
Bauer, Sebastian;Kleber, Sebastian;Schmuki, Patrik
通讯作者：
Schmuki, Patrik
影响因子：
5.4
作者：
Biggs, Manus Jonathan Paul;Richards, R. Geoff;Dalby, Matthew J.
通讯作者：
Dalby, Matthew J.
影响因子：
4.9
作者：
Amaral, M.;Dias, A. G.;Fernandes, M. H.
通讯作者：
Fernandes, M. H.
影响因子：
4.9
作者：
Balasundaram, Ganesan;Webster, Thomas J.
通讯作者：
Webster, Thomas J.