Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions.
Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions.
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DOI：
10.1016/j.neuroimage.2015.04.015
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发表时间：
2015-07-15
期刊：
影响因子：
5.7
通讯作者：
Nosarti C
中科院分区：
文献类型：
--
作者：
Nam KW;Castellanos N;Simmons A;Froudist-Walsh S;Allin MP;Walshe M;Murray RM;Evans A;Muehlboeck JS;Nosarti C
极早产（胎龄<33周）与皮质厚度的改变和神经心理/行为障碍有关。在这里，我们研究了非常早产的个体和对照组在青春期中期（平均年龄15岁）和成年期开始（平均年龄20岁）的皮质厚度，以及两个时间点之间的纵向变化。使用单变量方法，我们发现与对照组相比，极早产儿的皮质厚度增加和减少。具体而言，（1）非常早产的青少年表现出广泛的皮质厚度较大的区域，特别是在枕颞和前额皮质，这种差异在成年早期大幅减少;（2）在这两个时间点，非常早产的参与者表现出较小的皮质厚度，特别是在海马旁和岛叶区域。然后，我们采用多变量方法（支持向量机）来研究两组之间的空间区分功能，平均准确率为86.5%。皮质厚度最好区分各组（前5%）的空间分布区域包括颞叶、枕颞叶、顶叶和前额叶皮质。在这些空间分布的区域（前1%），纵向变化的皮质厚度在左颞极，右枕颞回和左上级顶叶与分数的语言为基础的测试执行功能。这些结果描述了早产儿个体在其生命的第二个十年中皮质厚度发育的变化，并对高阶认知处理产生影响。极早产儿的皮质厚度出现长期变化，这种变化主要影响额叶和颞叶皮质。多变量分析显示组间空间区分特征，准确率为86.5%。纵向皮质厚度变化与执行功能评分相关。
Very preterm birth (gestational age < 33 weeks) is associated with alterations in cortical thickness and with neuropsychological/behavioural impairments. Here we studied cortical thickness in very preterm born individuals and controls in mid-adolescence (mean age 15 years) and beginning of adulthood (mean age 20 years), as well as longitudinal changes between the two time points. Using univariate approaches, we showed both increases and decreases in cortical thickness in very preterm born individuals compared to controls. Specifically (1) very preterm born adolescents displayed extensive areas of greater cortical thickness, especially in occipitotemporal and prefrontal cortices, differences which decreased substantially by early adulthood; (2) at both time points, very preterm-born participants showed smaller cortical thickness, especially in parahippocampal and insular regions. We then employed a multivariate approach (support vector machine) to study spatially discriminating features between the two groups, which achieved a mean accuracy of 86.5%. The spatially distributed regions in which cortical thickness best discriminated between the groups (top 5%) included temporal, occipitotemporal, parietal and prefrontal cortices. Within these spatially distributed regions (top 1%), longitudinal changes in cortical thickness in left temporal pole, right occipitotemporal gyrus and left superior parietal lobe were significantly associated with scores on language-based tests of executive function. These results describe alterations in cortical thickness development in preterm-born individuals in their second decade of life, with implications for high-order cognitive processing. Individuals born very preterm showed long-term alterations in cortical thickness Such alterations affected predominantly frontal and temporal cortices Multivariate analysis revealed between-group spatially discriminating features, with 86.5% accuracy Longitudinal cortical thickness changes were associated with executive function scores
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
2.8
作者：
Ardila A;Bernal B;Rosselli M
通讯作者：
Rosselli M
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作者：
Benetti, Stefania;Mechelli, Andrea;McGuire, Philip
通讯作者：
McGuire, Philip
使用扩散张量成像对人类颞极进行基于连通性的分割
影响因子：
3.7
作者：
Fan, Lingzhong;Wang, Jiaojian;Jiang, Tianzi
通讯作者：
Jiang, Tianzi
影响因子：
25.8
作者：
Ecker, Christine;Ginestet, Cedric;Murphy, Declan G. M.
通讯作者：
Murphy, Declan G. M.