Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats
Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats
复制标题
急性低度酒精通过抑制 PKA/CREB 通路破坏大鼠海马-纹状体学习策略的神经关联
DOI：
10.3389/fphar.2018.01439
复制
发表时间：
2018-12
影响因子：
5.6
通讯作者：
Lei An
中科院分区：
文献类型：
--
作者：
Wei Sun;Xiaoliang Li;Chunzhi Tang;Lei An
The hippocampus and striatum guide place-strategy and response-strategy learning, respectively, and they have dissociable roles in memory systems, which could compensate in case of temporary or permanent damage. Although acute alcohol (AA) treatment had been shown to have adverse effects on hippocampal function, whether it causes the functional compensation and the underlying mechanisms is unknown. In this study, rats treated with a low dose of AA avoided a hippocampus-dependent spatial strategy, instead preferring a striatum-dependent response strategy. Consistently, the learning-induced increase in hippocampal, but not striatal, pCREB was rendered less pronounced due to diminished activity of pPKA, but not pERK or pCaMKII. As rats approached the turn-decision area, Sp-cAMP, a PKA activator, was found to mitigate the inhibitory effect of AA on intra- and cross-structure synchronized neuronal oscillations, and rescue response-strategy bias and spatial learning deficits. Our study provides strong evidence of the critical link between neural couplings and strategy selection. Moreover, the PKA/CREB-signaling pathway is involved in the suppressive effect of AA on neural correlates of place-learning strategy. The novel important evidence provided here shows the functional couplings between the hippocampus and striatum in spatial learning processing and suggests possible avenues for therapeutic intervention.
登录
查看更多内容
DOI：
10.1111/acer.13144
发表时间：
2016-07
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Yameng Zhang;Hejuan Yu;Weitao Li;Yamin Yang;Xiao Wang;Z. Qian
通讯作者：
Yameng Zhang;Hejuan Yu;Weitao Li;Yamin Yang;Xiao Wang;Z. Qian
影响因子：
3.5
作者：
A. Weitemier;A. Ryabinin
通讯作者：
A. Weitemier;A. Ryabinin
DOI：
10.1111/acer.12310
发表时间：
2014-03
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Jaewon Lee;K. Yun
通讯作者：
Jaewon Lee;K. Yun
影响因子：
3.3
作者：
J. Zhang;F. Okutani;S. Inoue;H. Kaba
通讯作者：
J. Zhang;F. Okutani;S. Inoue;H. Kaba
影响因子：
2.3
作者：
Abramson, Charles I.;Craig, David Philip Arthur;Wells, Harrington
通讯作者：
Wells, Harrington