Epidemic myalgia in adults associated with human parechovirus type 3 infection, Yamagata, Japan, 2008.
Epidemic myalgia in adults associated with human parechovirus type 3 infection, Yamagata, Japan, 2008.
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DOI：
10.3201/eid1811.111570
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发表时间：
2012-11
影响因子：
11.8
通讯作者：
Ahiko T
中科院分区：
文献类型：
--
作者：
Mizuta K;Kuroda M;Kurimura M;Yahata Y;Sekizuka T;Aoki Y;Ikeda T;Abiko C;Noda M;Kimura H;Mizutani T;Kato T;Kawanami T;Ahiko T
这种病毒通常导致幼儿患病，但发现与成人患病有关。人类双埃柯病毒很少被证明会引起成人的临床疾病。2008年6月至8月期间，共有22名成年人因肌肉疼痛和四肢无力在日本山形米泽市立医院寻求治疗;大多数人还发烧和喉咙痛。所有患者均接受流行性肌痛的临床诊断;临床实验室检查结果提示急性炎症过程。14例患者实验室确诊为人双埃柯病毒3型（HPeV3）感染，其中7例患者分离HPeV3，11例患者进行HPeV3基因组检测，11例患者进行血清学确诊。虽然HPeV3通常与幼儿疾病有关，但我们的研究结果表明，成人肌痛的爆发与HPeV3感染有关。当社区爆发HPeV3时，不仅应在幼儿中，还应在成人中考虑HPeV3的临床问题。
This virus typically causes illness in young children but was found to be associated with illness in adults. Human parechovirus has rarely been shown to cause clinical disease in adults. During June–August 2008, a total of 22 adults sought treatment at Yonezawa City Hospital in Yamagata, Japan, for muscle pain and weakness of all limbs; most also had fever and sore throat. All patients received a clinical diagnosis of epidemic myalgia; clinical laboratory findings suggested an acute inflammatory process. Laboratory confirmation of infection with human parechovirus type 3 (HPeV3) was made for 14 patients; we isolated HPeV3 from 7 patients, detected HPeV3 genome in 11, and observed serologic confirmation of infection in 11. Although HPeV3 is typically associated with disease in young children, our results suggest that this outbreak of myalgia among adults was associated with HPeV3 infection. Clinical consideration should be given to HPeV3 not only in young children but also in adults when an outbreak occurs in the community.
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影响因子：
9.4
作者：
Ito, Miyabi;Yamashita, Teruo;Minagawa, Hiroko
通讯作者：
Minagawa, Hiroko
影响因子：
9.4
作者：
Nix, W. Allan;Maher, Kaija;Oberste, M. Steven
通讯作者：
Oberste, M. Steven
影响因子：
9.4
作者：
van der Sanden, Sabine;de Bruin, Erwin;van der Avoort, Harrie
通讯作者：
van der Avoort, Harrie
DOI：
10.1016/j.diagmicrobio.2010.05.016
发表时间：
2010-10-01
影响因子：
2.9
作者：
Benschop, Kimberley;Minnaar, Rene;Wolthers, Katja
通讯作者：
Wolthers, Katja
影响因子：
7
作者：
Chaisson, Mark J.;Brinza, Dumitru;Pevzner, Pavel A.
通讯作者：
Pevzner, Pavel A.