Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles

Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles
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聚乙二醇化磷脂膜包覆层状双氢氧化物纳米粒子的制备及评价

DOI:
10.1016/j.ajps.2015.09.003
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发表时间:
2016-06
影响因子:
10.2
通讯作者:
Chunshun Zhao
Chunshun Zhao
中科院分区:
医学1区
文献类型:
--
作者:
Ke Zeng;Yunhui Liao;Yihui Deng;Chunshun Zhao

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本研究的目的是制备聚乙二醇化磷脂膜包裹的层状双氢氧化物(LDH)纳米粒子。通过比较粒径分布和zeta电位,确定乳酸脱氢酶与构成外膜的脂类物质的质量比为2:1。透射电子显微镜照片证实了聚乙二醇化磷脂膜包裹的乳酸脱氢酶纳米粒的核壳结构,细胞毒性实验表明其在0.5~5 0 μg/m L范围内对Hela和BALB/C-3T3细胞具有良好的细胞活性。
The aim of the present study was to develop layered double hydroxide (LDH) nanoparticles coated with PEGylated phospholipid membrane. By comparing the size distribution and zeta potential, the weight ratio of LDH to lipid materials which constitute the outside membrane was identified as 2:1. Transmission electron microscopy photographs confirmed the core-shell structure of PEGylated phospholipid membrane coated LDH (PEG-PLDH) nanoparticles, and cell cytotoxicity assay showed their good cell viability on Hela and BALB/C-3T3 cells over the concentration range from 0.5 to 50 μg/mL.
DOI: 10.1021/cm040056i
发表时间: 2004-11-30
影响因子: 8.6
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