Scrub typhus, a disease with increasing threat in Guangdong, China.
Scrub typhus, a disease with increasing threat in Guangdong, China.
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DOI：
10.1371/journal.pone.0113968
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yan LJ
中科院分区：
文献类型：
--
作者：
De W;Jing K;Huan Z;Qiong ZH;Monagin C;Min ZJ;Ping H;Wen KC;Yan LJ
中国说，广东省的丛林斑疹伤寒病例增长迅速。为此，对广东省丛林斑疹伤寒流行特点进行了流行病学研究。从2006年到2013年，人间病例的发病率从每100 000人中的0.4321例增加到3.5917例，人间病例的双峰通常出现在5月至11月之间。为了解东方体在疑似病例和啮齿动物中的流行情况，对59例疑似病例的全血标本和112只啮齿动物的脾标本进行了IgM/Ig G和巢式聚合酶链式反应试验。疑似病例的抗O型抗体检测呈阳性。抗体阳性率分别为66.1%(39/59)和50.8%(30/59)。此外，20.3%(12/59)的血液和13.4%(15/112)的脾标本为阳性。系统发育树分析表明，56 kDa抗原基因的27个核苷酸序列中有4个可定义的簇：44.4%的Karp(12/27)、25.9%的Kato(7/27)、22.2%的Gilliam(6/27)和7.4%的TA763(2/27)。我们得出结论，许多疑似病例可能会导致诊断错误，因此，有必要在医院对疑似病例进行实验室检测。在被检测的有限啮齿动物中，恙虫病原虫感染率很高，这表明有必要在全省范围内进行进一步的啮齿动物抽样，以进一步确定高危地区。此外，多个共循环基因型在广东地区林木斑疹伤寒的流行中起着关键作用。
There has been a rapid increase in the number of scrub typhus cases in Guangdong Province, China. For this reason, an epidemiologic study was conducted to understand the characteristics of scrub typhus epidemics in Guangdong. From 2006 to 2013, the incidence of human cases increased from 0.4321 to 3.5917 per 100,000 with a bimodal peak in human cases typically occurring between May and November. To detect the prevalence of Orientia tsutsugamushi among suspected human cases and rodents, we performed ELISA tests of IgM/IgG and nested PCR tests on 59 whole blood samples from the suspected cases and 112 spleen samples from the rodents. Suspected cases tested positive for anti-O. tsutsugamushi IgM and IgG 66.1% (39/59) and 50.8% (30/59) of the time, respectively. Additionally, 20.3% (12/59) of blood samples and 13.4% (15/112) of spleen samples were positive for PCR. Phylogenetic analysis revealed that there were four definable clusters among the 27 nucleotide sequences of the 56-kDa antigen genes: 44.4% Karp (12/27), 25.9% Kato (7/27), 22.2% Gilliam (6/27) and 7.4% TA763 (2/27). We concluded many suspected cases may result in diagnostic errors; therefore, it is necessary to perform laboratory tests on suspected cases in hospitals. The high infection rate of O. tsutsugamushi among the limited rodents tested suggested that further rodent sampling throughout the province is necessary to further define high-risk areas. Furthermore, the multiple co-circulating genotypes of O. tsutsugamushi play a key role in the pervasiveness of scrub typhus in the Guangdong area.
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中国山东省恙虫病的监测、临床概况和诊断问题
DOI：
10.4269/ajtmh.2012.12-0306
发表时间：
2012-12-01
影响因子：
3.3
作者：
Zhang, Meng;Zhao, Zhong-Tang;Ding, Shu-Jun
通讯作者：
Ding, Shu-Jun
影响因子：
4.5
作者：
Kim YJ;Yeo SJ;Park SJ;Woo YJ;Kim MW;Kim SH;Chang IA;Jeon SH;Park BJ;Song GJ;Lee MG;Kim IS;Kim YW
通讯作者：
Kim YW
影响因子：
2.6
作者：
Ohashi, N;Koyama, Y;Yoshimura, K
通讯作者：
Yoshimura, K
影响因子：
3.2
作者：
Duong, Veasna;Trinh Thi Xuan Mai;Buchy, Philippe
通讯作者：
Buchy, Philippe
影响因子：
9.4
作者：
Ruang-areerate, Toon;Jeamwattanalert, Pimmada;Gaywee, Jariyanart
通讯作者：
Gaywee, Jariyanart