Current perspectives on the role of CD8+ T cells in systemic sclerosis.
Current perspectives on the role of CD8+ T cells in systemic sclerosis.
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DOI：
10.1016/j.imlet.2017.10.002
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发表时间：
2018-03
影响因子：
4.4
通讯作者：
Fuschiotti P
中科院分区：
文献类型：
--
作者：
Fuschiotti P
尽管长期以来人们认识到T细胞在系统性硬化症（SSc；硬皮病）中的重要性，但CD8+ T细胞在疾病发病机制中的作用尚未得到很好的研究。我们的研究表明，外周血效应/记忆性CD8+ T细胞过度产生促纤维化细胞因子IL-13是使患者易患更严重形式的皮肤纤维化的关键。此外，产生il -13的CD8+ T细胞在正常和SSc真皮成纤维细胞中诱导促纤维化表型，并在体外表现出很强的细胞毒活性。我们还发现，与晚期疾病患者相比，弥漫性皮肤（dc）SSc早期患者的皮肤病变中CD8+ T细胞主要丰富。从早期活动性dcSSc患者的病变皮肤中分离CD8+ T细胞，证实它们是皮肤常驻细胞，表达细胞溶解分子，并共同表达极高水平的IL-13和IFNγ。最近的其他研究证实了这些发现，并共同强烈表明CD8+ T细胞通过产生高水平的具有促炎和促纤维化功能的细胞因子以及表现出细胞毒性活性来促进SSc的发病。
Despite long-standing recognition of the importance of T cells in systemic sclerosis (SSc; scleroderma), the role of CD8+ T cells in disease pathogenesis has not been well studied. Our work has shown that over-production of the pro-fibrotic cytokine IL-13 by peripheral blood effector/memory CD8+ T cells is critical for predisposing patients to more severe forms of cutaneous fibrosis. Moreover, IL-13-producing CD8+ T cells induce a pro-fibrotic phenotype in normal and SSc dermal fibroblasts, and exhibit a strong cytotoxic activity ex vivo. We also found that CD8+ T cells are predominantly abundant in the skin lesions of patients in the early stages of diffuse cutaneous (dc)SSc compare to late-stage disease patients. Isolation of CD8+ T cells from the lesional skin of early active dcSSc patients, established that they are skin-resident, express cytolytic molecules and co-express extremely high levels of IL-13 and IFNγ. Other recent studies corroborate these findings and together strongly suggest that CD8+ T cells contribute to SSc pathogenesis through the production of high levels of cytokines with proinflammatory and pro-fibrotic function as well as by exhibiting a cytotoxic activity.
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影响因子：
4.9
作者：
Brembilla NC;Montanari E;Truchetet ME;Raschi E;Meroni P;Chizzolini C
通讯作者：
Chizzolini C
影响因子：
17.1
作者：
Clark RA
通讯作者：
Clark RA
影响因子：
8.6
作者：
Fenoglio, Daniela;Battaglia, Florinda;Filaci, Gilberto
通讯作者：
Filaci, Gilberto
影响因子：
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作者：
Dvergsten, Jeffrey A.;Mueller, Robert G.;Vallejo, Abbe N.
通讯作者：
Vallejo, Abbe N.
影响因子：
27.4
作者：
GUSTAFSSON, R;TOTTERMAN, TH;HALLGREN, R
通讯作者：
HALLGREN, R