Host-microbe interactions and the behavior of Caenorhabditis elegans.
Host-microbe interactions and the behavior of Caenorhabditis elegans.
复制标题
宿主 - 微生物相互作用和秀丽隐杆线虫的行为。
DOI：
10.1080/01677063.2020.1802724
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发表时间：
2020-09
影响因子：
1.9
通讯作者：
Flavell SW
中科院分区：
文献类型：
--
作者：
Kim DH;Flavell SW
微生物在秀丽隐杆线虫的自然环境中无处不在。细菌是线虫的食物来源，但也可能引起线虫宿主的感染。秀丽隐杆线虫的感觉神经系统可检测多种微生物分子，从大类细菌产生的代谢物到特定细菌菌株合成的分子。通过细菌代谢物的化学感觉或细菌的机械感觉进行的先天识别可以诱导立即的行为反应。摄入营养性或致病性细菌可以调节导致长期行为变化的内部状态。摄入营养细菌会导致对细菌食物来源的习得性吸引和利用。感染伴随着先天免疫的激活、应激反应和宿主损伤，导致厌恶行为的发展。环境中多种微生物感官线索的整合是由经验和环境决定的。对秀丽隐杆线虫在细菌存在下行为的遗传、化学和神经元研究已经确定了神经回路和神经调节系统，这些系统塑造了对微生物线索的先天和后天行为反应。这些研究揭示了宿主-微生物相互作用对控制这种简单动物宿主行为的深远影响。
Microbes are ubiquitous in the natural environment of Caenorhabditis elegans. Bacteria serve as a food source for C. elegans but may also cause infection in the nematode host. The sensory nervous system of C. elegans detects diverse microbial molecules, ranging from metabolites produced by broad classes of bacteria to molecules synthesized by specific strains of bacteria. Innate recognition through chemosensation of bacterial metabolites or mechanosensation of bacteria can induce immediate behavioral responses. The ingestion of nutritive or pathogenic bacteria can modulate internal states that underlie long-lasting behavioral changes. Ingestion of nutritive bacteria leads to learned attraction and exploitation of the bacterial food source. Infection, which is accompanied by activation of innate immunity, stress responses, and host damage, leads to the development of aversive behavior. The integration of a multitude of microbial sensory cues in the environment is shaped by experience and context. Genetic, chemical, and neuronal studies of C. elegans behavior in the presence of bacteria have defined neural circuits and neuromodulatory systems that shape innate and learned behavioral responses to microbial cues. These studies have revealed the profound influence that host-microbe interactions have in governing the behavior of this simple animal host.
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影响因子：
64.5
作者：
BARGMANN, CI;HARTWIEG, E;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
9.8
作者：
Chang AJ;Chronis N;Karow DS;Marletta MA;Bargmann CI
通讯作者：
Bargmann CI
影响因子：
3.1
作者：
Couillault, C;Ewbank, JJ
通讯作者：
Ewbank, JJ
影响因子：
25
作者：
Barrios, Arantza;Ghosh, Rajarshi;Fang, Chunhui;Emmons, Scott W.;Barr, Maureen M.
通讯作者：
Barr, Maureen M.
DOI：
10.1073/pnas.0409009101
发表时间：
2005-03-01
影响因子：
11.1
作者：
Gray, JM;Hill, JJ;Bargmann, CI
通讯作者：
Bargmann, CI