A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.
A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.
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DOI：
10.3390/cells10051164
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发表时间：
2021-05-11
期刊：
影响因子：
6
通讯作者：
Buchanan SK
中科院分区：
文献类型：
--
作者：
Pitt AS;Buchanan SK
线粒体在细胞稳态中发挥的核心作用使其研究对我们理解人类健康和疾病的各个方面至关重要。线粒体依赖于外膜转位酶（TOM）复合体的大部分线粒体蛋白的进口。除了作为线粒体蛋白的主要入口外，TOM复合体还作为病毒蛋白的入口途径。TOM复合体亚基还参与一系列相互作用，这些相互作用在神经退行性疾病、心血管疾病、先天免疫、癌症、代谢、有丝分裂和自噬等方面的功能已被广泛研究。最近我们对线粒体外膜TOM复合物和蛋白质进口机制的结构理解取得了进展，这使得线粒体功能障碍期间靶向线粒体外膜蛋白的基于结构的治疗方法具有令人兴奋的前景。在这里，我们描述了在理解TOM复合体、TOM复合体亚基的相互作用组、治疗学发展的意义以及我们对TOM复合体组成部分与线粒体稳态之间结构/功能关系的理解方面的进展。
The central role mitochondria play in cellular homeostasis has made its study critical to our understanding of various aspects of human health and disease. Mitochondria rely on the translocase of the outer membrane (TOM) complex for the bulk of mitochondrial protein import. In addition to its role as the major entry point for mitochondrial proteins, the TOM complex serves as an entry pathway for viral proteins. TOM complex subunits also participate in a host of interactions that have been studied extensively for their function in neurodegenerative diseases, cardiovascular diseases, innate immunity, cancer, metabolism, mitophagy and autophagy. Recent advances in our structural understanding of the TOM complex and the protein import machinery of the outer mitochondrial membrane have made structure-based therapeutics targeting outer mitochondrial membrane proteins during mitochondrial dysfunction an exciting prospect. Here, we describe advances in understanding the TOM complex, the interactome of the TOM complex subunits, the implications for the development of therapeutics, and our understanding of the structure/function relationship between components of the TOM complex and mitochondrial homeostasis.
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DOI：
10.1083/jcb.201708044
发表时间：
2018-04-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Backes S;Hess S;Boos F;Woellhaf MW;Gödel S;Jung M;Mühlhaus T;Herrmann JM
通讯作者：
Herrmann JM
α-突触核蛋白与TOM20结合，并抑制在帕金森氏病中进口的线粒体蛋白。
影响因子：
17.1
作者：
Di Maio R;Barrett PJ;Hoffman EK;Barrett CW;Zharikov A;Borah A;Hu X;McCoy J;Chu CT;Burton EA;Hastings TG;Greenamyre JT
通讯作者：
Greenamyre JT
影响因子：
11.4
作者：
Bolliger, L;Junne, T;Lithgow, T
通讯作者：
Lithgow, T
影响因子：
3.5
作者：
Cartron, Pierre-Francois;Bellot, Gregory;Vallette, Francois M.
通讯作者：
Vallette, Francois M.
影响因子：
12.4
作者：
Bellot, G.;Cartron, P. -F.;Vallette, F. M.
通讯作者：
Vallette, F. M.