Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans.
Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans.
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DOI：
10.3390/md11072682
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发表时间：
2013-07-23
期刊：
影响因子：
5.4
通讯作者：
Wang BG
中科院分区：
文献类型：
--
作者：
An CY;Li XM;Li CS;Wang MH;Xu GM;Wang BG
从海洋红树林植物红海榄（Rhizophora stylosa）叶片内生真菌构巢曲霉（Aspergillus nidulans）MA-143的培养物中分离并鉴定了4个新的喹唑啉酮生物碱，即阿尼喹唑啉A-D（1-4）。新化合物的结构通过光谱分析进行了鉴定，其绝对构型通过手性HPLC分析的基础上确定的酸水解产物。通过单晶X射线衍射分析证实了1的结构。所有这些化合物的抗菌和细胞毒活性以及卤虫（卤虫）的致死率进行了检查。
Four new quinazolinone alkaloids, namely, aniquinazolines A–D (1–4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
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