Reverse zoonosis of influenza to swine: new perspectives on the human-animal interface.
Reverse zoonosis of influenza to swine: new perspectives on the human-animal interface.
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DOI:
10.1016/j.tim.2014.12.002
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发表时间:
2015-03
影响因子:
15.9
通讯作者:
Vincent, Amy L.
中科院分区:
文献类型:
--
作者:
Nelson, Martha I.;Vincent, Amy L.
The origins of the influenza A (H1N1) pandemic of 2009 in swine are unknown, highlighting gaps in our understanding of influenza A virus ecology and evolution. Here we review how recently strengthened influenza virus surveillance in pigs has revealed that influenza virus transmission from humans to swine is far more frequent than swine-to-human zoonosis, and is central in seeding swine globally with new viral diversity. The scale of global human-to-swine transmission represents the largest ‘reverse zoonosis’ of a pathogen documented to date. Overcoming the bias towards perceiving swine as sources of human viruses, rather than recipients, is key to understanding how the bidirectional nature of the human-animal interface produces influenza threats to both hosts.
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