Emotion, cognition, and mental state representation in amygdala and prefrontal cortex.

Emotion, cognition, and mental state representation in amygdala and prefrontal cortex.
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DOI:
10.1146/annurev.neuro.051508.135256
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发表时间:
2010
影响因子:
13.9
通讯作者:
Fusi S
Fusi S
中科院分区:
医学1区
文献类型:
--
作者:
Salzman CD;Fusi S

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神经科学家经常将认知和情感描述为由大脑不同区域执行的可分离过程,例如杏仁核用于情感,前额叶皮层用于认知。在这个框架中,杏仁核和前额叶皮层之间的功能相互作用介导了对认知过程(如决策)的情绪影响,以及对情绪的认知调节。然而,这些结构中的神经元通常具有纠缠的表征,从而单个神经元编码多个认知和情感变量。在这里,我们回顾研究使用解剖,病变和神经生理学的方法来调查的代表性和利用的认知和情绪参数。我们提出,这些心理状态参数是密不可分的,并表示在动态神经网络组成的相互连接的前额叶和边缘脑结构。未来的理论和实验工作需要了解这些心理状态表征如何形成,以及心理状态之间的转换如何发生,这是适应性认知和情感行为的关键特征。
Neuroscientists have often described cognition and emotion as separable processes implemented by different regions of the brain, such as the amygdala for emotion and the prefrontal cortex for cognition. In this framework, functional interactions between the amygdala and prefrontal cortex mediate emotional influences on cognitive processes such as decision-making, as well as the cognitive regulation of emotion. However, neurons in these structures often have entangled representations, whereby single neurons encode multiple cognitive and emotional variables. Here we review studies using anatomical, lesion, and neurophysiological approaches to investigate the representation and utilization of cognitive and emotional parameters. We propose that these mental state parameters are inextricably linked and represented in dynamic neural networks composed of interconnected prefrontal and limbic brain structures. Future theoretical and experimental work is required to understand how these mental state representations form and how shifts between mental states occur, a critical feature of adaptive cognitive and emotional behavior.
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