In vivo human choroidal thickness measurements: evidence for diurnal fluctuations.
In vivo human choroidal thickness measurements: evidence for diurnal fluctuations.
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DOI：
10.1167/iovs.08-1779
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发表时间：
2009-01
影响因子：
4.4
通讯作者：
Stone RA
中科院分区：
文献类型：
--
作者：
Brown JS;Flitcroft DI;Ying GS;Francis EL;Schmid GF;Quinn GE;Stone RA
作者应用部分相干干涉测量法（PCI）来估计体内人脉络膜的厚度，并了解它在白天是否波动。通过将信号处理技术应用于人类眼轴长度测量的现有PCI示图，开发并验证了一种信号建模算法，以确定膜后峰的位置和变异性，通过类比动物研究，该峰可能对应于脉络膜/巩膜界面。然后将该算法应用于昼夜眼轴长度数据集。在开发和验证数据集中，28%的受试者发现了眶后峰，平均中央凹下脉络膜厚度分别为307 μm和293 μm。40个PCI日数据集中有28个至少有两个时间点具有可识别的血管后峰，平均脉络膜厚度为426 μm，平均高低差为59.5±24.2 μm（范围25.9-103 μm）。在这28个数据集中，有16个数据集的脉络膜厚度日波动大于测量误差（24.5 μm）的2倍。轴向长度和脉络膜厚度呈反相波动。信号处理技术提供脉络膜厚度估计在许多，但不是全部，PCI数据集轴眼测量。基于在一天中不止一次出现可识别的视网膜电位峰的眼睛，脉络膜厚度在一天内发生变化。由于脉络膜在视网膜功能中的作用及其在调节眼睛生长中的可能作用，进一步发展和完善临床测量其厚度的方法是必要的。
The authors applied partial coherence interferometry (PCI) to estimate the thickness of the human choroid in vivo and to learn whether it fluctuates during the day. By applying signal processing techniques to existing PCI tracings of human ocular axial length measurements, a signal modeling algorithm was developed and validated to determine the position and variability of a postretinal peak that, by analogy to animal studies, likely corresponds to the choroidal/scleral interface. The algorithm then was applied to diurnal axial eye length datasets. The postretinal peak was identified in 28% of subjects in the development and validation datasets, with mean subfoveal choroidal thicknesses of 307 and 293 μm, respectively. Twenty-eight of 40 diurnal PCI datasets had at least two time points with identifiable postretinal peaks, yielding a mean choroidal thickness of 426 μm and a mean high-low difference in choroidal thickness of 59.5 ± 24.2 μm (range, 25.9–103 μm). The diurnal choroidal thickness fluctuation was larger than twice the SE of measurement (24.5 μm) in 16 of these 28 datasets. Axial length and choroidal thickness tended to fluctuate in antiphase. Signal processing techniques provide choroidal thickness estimates in many, but not all, PCI datasets of axial eye measurements. Based on eyes with identifiable postretinal peaks at more than one time in a day, choroidal thickness varied over the day. Because of the established role of the choroid in retinal function and its possible role in regulating eye growth, further development and refinement of clinical methods to measure its thickness are warranted.
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影响因子：
--
作者：
Quinn, GE;Francis, EL;Stone, RA
通讯作者：
Stone, RA
影响因子：
4.4
作者：
Stone, RA;Quinn, GE;Schmid, G
通讯作者：
Schmid, G
影响因子：
3.5
作者：
Wang, RKK
通讯作者：
Wang, RKK
影响因子：
3.4
作者：
Nickla, DL;Wildsoet, C;Wallman, J
通讯作者：
Wallman, J
影响因子：
1.8
作者：
WALLMAN, J;WILDSOET, C;CHRISTENSEN, AM
通讯作者：
CHRISTENSEN, AM