Fixel-based analysis reveals alterations is brain microstructure and macrostructure of preterm-born infants at term equivalent age.
Fixel-based analysis reveals alterations is brain microstructure and macrostructure of preterm-born infants at term equivalent age.
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DOI：
10.1016/j.nicl.2018.01.003
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Rose SE
中科院分区：
文献类型：
--
作者：
Pannek K;Fripp J;George JM;Fiori S;Colditz PB;Boyd RN;Rose SE
早产会严重影响大脑发育，经常导致不良的神经发育结果。使用扩散MRI的脑成像可以提供有价值的洞察发育中的大脑的微观结构特性。本研究的目的是建立是否最近推出的固定为基础的分析方法，其相关措施的纤维密度（FD），纤维束横截面（FC），纤维密度和束横截面（FDC），是适合于调查的早产儿大脑在长期等效年龄。本研究纳入了55例早产儿和20例足月儿的高角分辨率弥散加权成像（HARDI），在足月等效年龄进行扫描（3 T，64个方向，B = 2000 s/mm 2）。MRI检查时的月经后年龄和颅内体积（仅FC和FDC）被确定为混杂变量。出生时的胎龄与胼胝体压部的所有固定措施相关。与足月儿相比，早产儿在许多区域表现出FD、FC和FDC减少，包括胼胝体、前连合、皮质脊髓束、视放射和扣带。与无任何肉眼可见脑异常的早产儿相比，有轻微肉眼可见脑异常的早产儿显示出更广泛的降低;然而，在无脑异常和有轻微脑异常的早产儿之间观察到的差异很小。在FD和FDC确定的区域之外，FC显示早产儿与足月儿显著减少，突出了这些措施的补充作用。基于固定的分析确定了早产儿的微观结构和宏观结构异常，提供了比以前的扩散张量成像（DTI）为基础的方法更完整的早期大脑发育的图片。出生时胎龄与胼胝体压部测量值相关。无肉眼脑异常的早产儿与足月儿有差异。极轻微与未检测到异常的早产儿之间无差异。
Preterm birth causes significant disruption in ongoing brain development, frequently resulting in adverse neurodevelopmental outcomes. Brain imaging using diffusion MRI may provide valuable insight into microstructural properties of the developing brain. The aim of this study was to establish whether the recently introduced fixel-based analysis method, with its associated measures of fibre density (FD), fibre bundle cross-section (FC), and fibre density and bundle cross-section (FDC), is suitable for the investigation of the preterm infant brain at term equivalent age. High-angular resolution diffusion weighted images (HARDI) of 55 preterm-born infants and 20 term-born infants, scanned around term-equivalent age, were included in this study (3 T, 64 directions, b = 2000 s/mm2). Postmenstrual age at the time of MRI, and intracranial volume (FC and FDC only), were identified as confounding variables. Gestational age at birth was correlated with all fixel measures in the splenium of the corpus callosum. Compared to term-born infants, preterm infants showed reduced FD, FC, and FDC in a number of regions, including the corpus callosum, anterior commissure, cortico-spinal tract, optic radiations, and cingulum. Preterm infants with minimal macroscopic brain abnormality showed more extensive reductions than preterm infants without any macroscopic brain abnormality; however, little differences were observed between preterm infants with no and with minimal brain abnormality. FC showed significant reductions in preterm versus term infants outside regions identified with FD and FDC, highlighting the complementary role of these measures. Fixel-based analysis identified both microstructural and macrostructural abnormalities in preterm born infants, providing a more complete picture of early brain development than previous diffusion tensor imaging (DTI) based approaches. Gestational age at birth associated with measurements in corpus callosum splenium. Preterms without macroscopic brain abnormality show differences to term infants. No differences between preterms with minimal versus without abnormality detected.
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白质图的概率图在新生儿脑图集上具有已知相关功能：评估纵向出生和早产儿的纵向发育轨迹的应用。
影响因子：
5.7
作者：
Akazawa K;Chang L;Yamakawa R;Hayama S;Buchthal S;Alicata D;Andres T;Castillo D;Oishi K;Skranes J;Ernst T;Oishi K
通讯作者：
Oishi K
影响因子：
5.7
作者：
Nossin-Manor, Revital;Card, Dallas;Sled, John G.
通讯作者：
Sled, John G.
影响因子：
5.7
作者：
Eaton-Rosen, Zach;Melbourne, Andrew;Ourselin, Sebastien
通讯作者：
Ourselin, Sebastien
影响因子：
3.5
作者：
George, J. M.;Fiori, S.;Boyd, R. N.
通讯作者：
Boyd, R. N.
影响因子：
3.3
作者：
Raffelt, David;Tournier, J-Donald;Salvado, Olivier
通讯作者：
Salvado, Olivier