Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison.
Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison.
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DOI：
10.3389/fnbeh.2014.00047
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发表时间：
2014
影响因子：
3
通讯作者：
Bezard E
中科院分区：
文献类型：
--
作者：
Camus SM;Rochais C;Blois-Heulin C;Li Q;Hausberger M;Bezard E
背景：为了揭示重度抑郁症（MDD）的病因，重度抑郁症是世界范围内造成疾病负担的第三大原因，最近提出了行为学动物模型。我们之前的研究强调了单独饲养和社会饲养的农场饲养的食蟹猴中存在类似抑郁的特征。尽管在系统发育上接近，食蟹猴和恒河猴（生物医学研究中最常用的两种猕猴）在攻击、和解、气质或统治风格等多个层面上存在差异。研究人员探讨了一种圈养猕猴是否比另一种猕猴更容易出现重度抑郁症（MDD）症状的病理特征。方法：在养殖条件下收集行为数据（包括身体姿势、方向、注视方向、个体间距离和笼子中的位置）。使用经过公正验证的行为学扫描采样方法，然后进行多重对应和层次聚类分析，对 40 只单独饲养的恒河猴和 35 只社会饲养的恒河猴进行了评估。独立地，对于每种饲养条件，都与之前获得的农场饲养的食蟹猴的数据进行了物种间比较。结果：与我们之前的研究一致，我们在单独饲养和群养的恒河猴中发现了类似抑郁的特征（例如，不活动、调查和维护水平低、长时间面朝墙壁不活动）。在非抑郁时间预算和病理特征的患病率中报告了物种特异性。结论：我们的结果表明，无论是在单独饲养环境还是在社会饲养条件下，恒河猴可能比食蟹猴更容易陷入绝望状态。因此，恒河猴更适合用作抑郁症的“自发”模型。
Background: To unravel the causes of major depressive disorder (MDD), the third leading cause of disease burden around the world, ethological animal models have recently been proposed. Our previous studies highlighted a depressive-like profile among single- and socially-housed farm-bred cynomolgus macaques. Although phylogenetically close, cynomolgus and rhesus macaques, the two most commonly used macaque species in biomedical research, differ on several levels such as patterns of aggression, reconciliation, temperament, or dominance styles. The question of whether one captive macaque species was more vulnerable than another in the development of a pathological profile reminiscent of MDD symptoms was explored. Methods: Behavioral data (including body postures, orientations, gaze directions, inter-individual distances, and locations in the cage) were collected in farming conditions. Using an unbiased validated ethological scan-sampling method, followed by multiple correspondence and hierarchical clustering analyses, 40 single- and 35 socially-housed rhesus macaques were assessed. Independently, for each housing condition, inter-species comparisons were made with previously acquired data on farm-bred cynomolgus monkeys. Results: Consistent with our previous studies, we found depressive-like characteristics (e.g., inactivity, low level of investigation and maintenance, long time spent inactive while facing the wall) among single- and socially-housed rhesus macaques. Species-specificities were reported in non-depressive time budgets and in the prevalence of the pathological profiles. Conclusions: Our results suggest that rhesus may be more vulnerable to developing a despair-like state than cynomolgus macaques, both in single- and in social-housing conditions. Therefore, rhesus macaques are more suitable for use as a “spontaneous” model of depressive disorders.
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影响因子：
0.7
作者：
Gilbert MH;Baker KC
通讯作者：
Baker KC
影响因子：
3.4
作者：
Claessens, Sanne E. F.;Daskalakis, Nikolaos P.;van der Veen, Rixt;Oitzl, Melly S.;de Kloet, E. Ronald;Champagne, Danielle L.
通讯作者：
Champagne, Danielle L.
影响因子：
3.7
作者：
Camus SM;Blois-Heulin C;Li Q;Hausberger M;Bezard E
通讯作者：
Bezard E
影响因子：
1.4
作者：
CROCKETT, CM;BOWERS, CL;SACKETT, GP
通讯作者：
SACKETT, GP
影响因子：
2.9
作者：
Daskalakis, Nikolaos P.;Oitzl, Melly S.;de Kloet, E. Ronald
通讯作者：
de Kloet, E. Ronald