D-Serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference.
D-Serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference.
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DOI：
10.1016/j.neuropharm.2012.06.022
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发表时间：
2013-01
影响因子：
4.7
通讯作者：
Wagner JJ
中科院分区：
文献类型：
--
作者：
Hammond S;Seymour CM;Burger A;Wagner JJ
成瘾是一种疾病，其特征是尽管对健康和社会造成负面影响，但仍强迫性寻求和使用药物。治疗成瘾的一个障碍是，尽管长期戒断，但极易复发。复发可由药物预测刺激触发，如环境背景和药物相关线索，以及成瘾性药物本身。条件位置偏好（CPP）行为模型是研究这些药物预测刺激恢复药物寻求行为能力的一个有用的范式。本研究考察了d -丝氨酸（10 mg/kg、30 mg/kg和100 mg/kg）对古柯碱条件大鼠戒毒训练和药物启动恢复的剂量依赖性。在第一个实验中，d -丝氨酸对可卡因诱导的运动致敏或CPP的获得或发展没有影响。在第二个实验中，d -丝氨酸治疗导致在完成消失方案后在药物配对室中花费的时间显着减少。一项可卡因启动恢复测试表明，戒毒训练与d -丝氨酸治疗相结合可显著减少药物寻求行为。第三个实验评估了d -丝氨酸对减少药物诱发恢复的长期影响。d -丝氨酸治疗在最后一次可卡因暴露后的4周以上的戒断期间有效地减少了药物寻求。这些发现表明d -丝氨酸可能是一种有效的辅助治疗药物，与认知行为疗法一起治疗可卡因成瘾。
Addiction is a disease that is characterized by compulsive drug-seeking and use despite negative health and social consequences. One obstacle in treating addiction is a high susceptibility for relapse which persists despite prolonged periods of abstinence. Relapse can be triggered by drug predictive stimuli such as environmental context and drug associated cues, as well as the addictive drug itself. The conditioned place preference (CPP) behavioral model is a useful paradigm for studying the ability of these drug predictive stimuli to reinstate drug-seeking behavior. The present study investigated the dose-dependent effects of D-serine (10 mg/kg, 30 mg/kg and 100 mg/kg) on extinction training and drug-primed reinstatement in cocaine-conditioned rats. In the first experiment, D-serine had no effect on the acquisition or development of cocaine-induced locomotor sensitization or CPP. In the second experiment, D-serine treatment resulted in significantly decreased time spent in the drug-paired compartment following completion of an extinction protocol. A cocaine-primed reinstatement test indicated that the combination of extinction training along with D-serine treatment resulted in a significant reduction of drug-seeking behavior. The third experiment assessed D-serine’s long-term effects to diminish drug-primed reinstatement. D-serine treatment given during extinction was effective in reducing drug-seeking for more than four weeks of abstinence after the last cocaine exposure. These findings demonstrate that D-serine may be an effective adjunct therapeutic agent along with cognitive behavioral therapy for the treatment of cocaine addiction.
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影响因子：
8.2
作者：
Myers, Karyn M.;Carlezon, William A., Jr.
通讯作者：
Carlezon, William A., Jr.
影响因子：
3.3
作者：
Kelamangalath, L.;Wagner, J. J.
通讯作者：
Wagner, J. J.
影响因子：
7.6
作者：
Duffy, Steven;Labrie, Viviane;Roder, John C.
通讯作者：
Roder, John C.
影响因子：
2.7
作者：
Karasawa, Jun-Ichi;Hashimoto, Kenji;Chaki, Shigeyuki
通讯作者：
Chaki, Shigeyuki
影响因子：
1.9
作者：
Ledgerwood, L;Richardson, R;Cranney, J
通讯作者：
Cranney, J