MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain.
MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain.
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DOI：
10.1016/j.neuroimage.2013.11.052
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发表时间：
2014-04-01
期刊：
影响因子：
5.7
通讯作者：
Zaharchuk G
中科院分区：
文献类型：
--
作者：
Christen T;Pannetier NA;Ni WW;Qiu D;Moseley ME;Schuff N;Zaharchuk G
在这项研究中，我们描述了一种指纹方法来分析磁共振信号的时间演变，并检索关于微血管网络的定量信息。我们使用了自由感应衰减和自旋回声(GESFIDE)序列的梯度回声采样，并将指纹定义为注射铁基造影剂前后采集的信号的比率。然后，我们用一种先进的数值工具模拟了同样的实验，该工具以包含血管的虚拟体素为输入，然后计算微观磁场和水扩散效应，最终得出预期的磁共振信号演变。改变模拟的参数输入(脑血容量[CBV]、平均血管半径[R]和血氧饱和度[SO2])，以获得所有可能的信号演变的字典。然后使用最小二乘法确定观察到的指纹和字典之间的最佳匹配度。该方法在5名正常受试者中进行了评估，并将其结果与更传统的MR方法、CBV和R的稳态对比成像以及从上矢状窦获得的SO2的整体氧合测量结果进行了比较。指纹方法能够创建高分辨率的微血管网络参数图，显示预期的对比度和精细细节。灰质的数值(CBV=3.1±0.7%，R=12.6±2.4µm，SO2=59.5±4.7%)与文献报道一致，并与常规MR方法相关。白质SO2值(53.0±4.0%)略低于预期。可以很容易地进行许多改进，这种方法应该对研究大脑病理很有用。
In the present study, we describe a fingerprinting approach to analyze the time evolution of the MR signal and retrieve quantitative information about the microvascular network. We used a Gradient Echo Sampling of the Free Induction Decay and Spin Echo (GESFIDE) sequence and defined a fingerprint as the ratio of signals acquired pre and post injection of an iron based contrast agent. We then simulated the same experiment with an advanced numerical tool that takes a virtual voxel containing blood vessels as input, then computes microscopic magnetic fields and water diffusion effects, and eventually derives the expected MR signal evolution. The parameters inputs of the simulations (cerebral blood volume [CBV], mean vessel radius [R], and blood oxygen saturation [SO2]) were varied to obtain a dictionary of all possible signal evolutions. The best fit between the observed fingerprint and the dictionary was then determined using least square minimization. This approach was evaluated in 5 normal subjects and the results were compared to those obtained using more conventional MR methods, steady-state contrast imaging for CBV and R and a global measure of oxygenation obtained from the superior sagittal sinus for SO2. The fingerprinting method enabled the creation of high-resolution parametric maps of the microvascular network showing expected contrast and fine details. Numerical values in gray matter (CBV=3.1±0.7%, R=12.6±2.4µm, SO2=59.5±4.7%) are consistent with literature reports and correlated with conventional MR approaches. SO2 values in white matter (53.0±4.0%) were slightly lower than expected. Numerous improvements can easily be made and the method should be useful to study brain pathologies.
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影响因子：
14.5
作者：
LEENDERS, KL;PERANI, D;JONES, T
通讯作者：
JONES, T
影响因子：
4.4
作者：
Haacke, E. M.;Tang, J.;Neelavalli, J.;Cheng, Y. C. N.
通讯作者：
Cheng, Y. C. N.
影响因子：
3.3
作者：
He, Xiang;Yablonskiy, Dmitriy A.
通讯作者：
Yablonskiy, Dmitriy A.
DOI：
10.1073/pnas.0610821104
发表时间：
2007-07-10
影响因子：
11.1
作者：
Duyn, Jeff H.;van Gelderen, Peter;Fukunaga, Masaki
通讯作者：
Fukunaga, Masaki
DOI：
10.1097/00004647-200008000-00008
发表时间：
2000-08-01
影响因子：
6.3
作者：
An, HY;Lin, WL
通讯作者：
Lin, WL