Dietary intake of selected B vitamins in relation to risk of major cancers in women.
Dietary intake of selected B vitamins in relation to risk of major cancers in women.
复制标题
DOI：
10.1038/sj.bjc.6604540
复制
发表时间：
2008-09-02
影响因子：
8.8
通讯作者：
Rohan, T. E.
中科院分区：
文献类型：
--
作者：
Kabat, G. C.;Miller, A. B.;Jain, M.;Rohan, T. E.
虽然叶酸已被研究其抑制致癌的潜力，但很少有流行病学研究评估摄入硫胺素、核黄素和烟酸的影响，它们可能作为叶酸代谢的辅助因子或通过其他机制降低癌症风险。使用来自加拿大妇女的大量队列数据，我们在平均16.4年的随访期间检查了这些营养素的饮食摄入，以及叶酸、蛋氨酸和酒精的摄入与乳腺癌、子宫内膜癌、卵巢癌、结直肠癌和肺癌的关系。排除后，可用于分析的事件病例数如下：乳腺，n=2491；子宫内膜,n = 426;卵巢,n = 264;colorectum n = 617;肺，n=358。使用Cox比例风险模型来估计每种癌症与单个营养素的风险，并探索营养素组合对癌症风险的可能影响。没有观察到个别B族维生素的摄入与这五种癌症有显著的联系。饮酒与患乳腺癌的风险呈适度正相关，但与患其他癌症的风险无关。没有证据表明营养素之间的效果发生了变化。这项大型研究几乎没有支持饮食摄入维生素、核黄素、烟酸、叶酸或蛋氨酸与女性五种主要癌症之间的联系。
Although folic acid has been investigated for its potential to inhibit carcinogenesis, few epidemiologic studies have assessed the effects of intake of thiamin, riboflavin, and niacin, which may reduce cancer risk by acting as cofactors in folate metabolism or by other mechanisms. Using data from a large cohort of Canadian women, we examined the association of dietary intake of these nutrients, as well as intake of folate, methionine, and alcohol, with cancers of the breast, endometrium, ovary, colorectum, and lung ascertained during an average of 16.4 years of follow-up. After exclusions, the following numbers of incident cases were available for analysis: breast, n=2491; endometrium, n=426; ovary, n=264; colorectum, n=617; and lung, n=358. Cox proportional hazard models were used to estimate risk of each cancer with individual nutrients and to explore possible effect modification by combinations of nutrients on cancer risk. Few significant associations of intake of individual B vitamins with the five cancers were observed. Alcohol consumption showed a modest positive association with breast cancer risk but not with risk of the other cancers. There was no evidence of effect modification among the nutrients. This large study provides little support for an association of dietary intake thiamin, riboflavin, niacin, folate, or methionine with five major cancers in women.
登录
查看更多内容
影响因子：
2.9
作者：
Harnack, L;Jacobs, DR;Folsom, AR
通讯作者：
Folsom, AR
影响因子：
5
作者：
Jain, M;Howe, GR;Rohan, T
通讯作者：
Rohan, T
影响因子：
13.6
作者：
Jain, MG;Rohan, TE;Miller, AB
通讯作者：
Miller, AB
影响因子：
10.3
作者：
Lewis, Sarah J.;Harbord, Roger M.;Smith, George Davey
通讯作者：
Smith, George Davey
影响因子：
2.3
作者：
Flood, A;Caprario, L;Schatzkin, A
通讯作者：
Schatzkin, A